外源性镁离子对重型颅脑创伤患者血清丙二醛含量的影响  

Effect of extrinsic ionized magnesium treatment on serum methylene dianiline in sTBI

作　　者：李建伟[1] 张赛[1] 

机构地区：[1]武警医学院附属医院脑系科中心,天津300162

出　　处：《武警医学院学报》2006年第6期549-551,共3页Acta Academiae Medicinae CPAPF

基　　金：天津市科委攻关项目(013111211)

摘　　要：[目的]探讨重型颅脑创伤患者硫酸镁治疗对患者血清丙二醛(MDA)含量及预后的影响。[方法] 54例入选病例按入院先后随机分为治疗组和对照组。治疗组首先15 min内静脉滴注2.5 g硫酸镁,接着10 g硫酸镁24 h持续静滴,连用3 d。对照组除硫酸镁外其他治疗完全相同。住院期间监测患者血清镁和MDA含量,伤后3个月纪录患者GOS评分。[结果]治疗组MDA含量低于对照组。治疗组GOS评分低于对照组,但没有统计学意义。[结论]重型颅脑创伤患者,硫酸镁能降低重型创伤性颅脑损伤患者血清MDA含量,可能有改善预后的趋势。[Objective] To investigate the relationship between MgSO4 therapy and serum methylene dianiline （MDA）, and the outcome of the patients with severe traumatic brain injury （sTBI）. [Methods] A prospective randomized singleblind clinical trial of MgSO4 therapy was performed in 54 cases with sTBI who were enrolled within 12 hours after injury, and intravenous MgSO4 was given in the treatment group, which was initiated with a bolus of 2.5 g in a 100-ml solution of 0.9% NaCl over 15 minutes, followed by continuous infusion at 0.4 g/hour （ 10 g in a 500 ml solution of 0.9% NaCl at 22.5 mE/hour） for 3 days. In control group, clinical management principles were the same as treatment group except MgSO4 was not given. Daily serum Mg^2＋ and MDA were monitored , and clinical outcomes were valued using the Glasgow Outcome Scale score （GOSs） at 3 months after injury. [Results] Decreased serum MDA were observed in the patients with treatment group as compared with the control group （ P 〈 0.05）. There was a slight but not significantly lower GOS score in treatment group as compared with the control group. [Conclusion] Intravenous MgSO4 can signifi- cantly reduce the serum MDA and Mg^2＋ has a role as a neuroprotective agent, and there is a trend of improving the pa- tients＇outcome.

关 键 词：硫酸镁 重型颅脑创伤 丙二醛 预后 临床试验 

分 类 号：R651.1[医药卫生—外科学]