金黄色葡萄球菌耐药性分析  

Antimicrobial resistance of Staphylococcus aureus isolates from Tongzhou District of Beijing

作　　者：张芳[1] 李玉敏[1] 崔会景[1] 王立秋[1] 车殿茹 刘静 

机构地区：[1]北京通州区潞河医院检验科,101149 [2]北京通州中医医院检验科 [3]北京通州妇幼保健院检验科

出　　处：《中国感染与化疗杂志》2006年第5期336-338,共3页Chinese Journal of Infection and Chemotherapy

摘　　要：目的了解金葡菌对常用抗菌药物的耐药情况,指导临床合理用药。方法对2002—2005年各类感染标本分离出的159株金葡菌使用纸片扩散法进行药敏试验和克林霉素诱导试验,并对结果进行分析。结果129株(81．1％)金葡菌为MR—SA,敏感度最高的5种抗菌药物依次为万古霉素(100％)、氯霉素(92．5％)、复方磺胺甲嗯唑(88．7％)、利福平(30．8％)和阿米卡星(26．4％)。D试验阳性率为63．6％。结论临床分离的金葡菌对常用抗菌药物产生多重耐药性．应根据分离株耐药特点选用不同的治疗方案。Objective To investigate current resistance pattern of Staphylococcus aureus isolates to common antimicrobial agents for improving clinical therapy. Methods A total of 159 isolates of S. aureus were collected from clinical settings during the period of 2002 to 2005. Disk diffusion method and D zone test were performed for all the strains. Results Of the 159 isolates, 129 （81.1 %） were identified as MRSA. All （100 %） the S. aureus isolates were susceptible to vancomycin, but variously to chloramphenicol （92.5%）, trimethoprim-sulfamethoxazole （88.7%）, rifampicin （30.8%）, and amikacin （26.4%）. The positive rate was 63.6% in D-test. Conclusions Clinical isolates of S. aureus are multiple-drug resistant. The antimicrobial therapy should be based on the resistant pattern.

关 键 词：金黄色葡萄球菌 耐药性 抗菌药物 

分 类 号：R446.5[医药卫生—诊断学]