灯盏细辛注射液对急性脑梗死患者血清粘附分子sICAM-1和CD11b/CD18的影响  

Effect of Erigeron Injection on Expresions of Adhesion molecules CD11b/CD18 and Solution Cell Adhesion Molecule-1 in Peripheral Blood of Patients with Acute Cerebral Infarction(ACI)

作　　者：王金良[1] 谭峰[1] 顾卫[1] 黄彪[1] 吴海科[1] 黄涛[1] 

机构地区：[1]广州中医药大学附属佛山中医院神经内科,广东广州528000

出　　处：《国际医药卫生导报》2006年第19期4-6,共3页International Medicine and Health Guidance News

基　　金：广东省佛山市卫生局科研立项项目编号(2003050)

摘　　要：目的观察灯盏细辛注射液对急性脑梗死(acutecerebralinfaction,ACI)患者的临床疗效及对血清粘附分子sICAM-1和CD11b/CD18表达的对影响。方法69例ACI患者随机分为灯盏细辛治疗组(36例)和常规治疗组(33例),采用双抗体夹心ELISA法、流式细胞仪(FCM)检测两组ACI患者治疗前后血清粘附分子sICAM-1和CD11b/CD18表达的水平。结果ACI患者治疗前血清粘附分子sICAM-1和CD11b/CD18的表达水平显著高于健康人组(p<0.05),灯盏细辛治疗组临床有效率明显高于常规治疗组(P<0.05),两组治疗后血清粘附分子sICAM-1和CD11b/CD18的表达均明显下降,灯盏细辛治疗组降低较常规治疗组更明显(p<0.05)。结论灯盏细辛注射液治疗ACI可能与其下调血清粘附分子sICAM-1和CD11b/CD18的表达,减轻中枢神经系统的炎性损伤密切相关。Objective To investigate the clinical effect of Erigeron Injection for acute cerebral infarction （ACI） and its influence on expresions of adhesion molecules CD11b/CD18 and solution cell adhesion molecule- 1 in peripheral blood of patients with ACI. Methods Sixty-nine patients with ACI were randomly divided into treated group and the conventional control group, expression of adhesion molecules CD11b/CD18 was measured by flow cytometry（FCM）, the expression of solution cell adhesion molecule-1 were measured serially with two- layer antibody sandwich ELISA before and after treatment . Results Expressions of adhesion molecules CD11b/CD18 and solution cell adhesion molecule-1 in the patients before treatment were all obviously higher than those in the normal control group（p〈0. 05）. The total curative effect in the treated group were significantly higher than in the contral group. All the two parameters were significantly decreased after treatment, and the lowering in the treated group was more significant than in the control group（p〈0. 05）. Conclusion The effection of Erigeron Injection on ACI patients may relate to its action in down-regulating the expression of adhesion molecules CD11b/CD18 and solution cell adhesion molecule- 1 ,allevating the inflammatory injury of central nervous system.

关 键 词：灯盏细辛注射液 急性脑梗死 SICAM-1 CD11B/CD18 

分 类 号：R277.7[医药卫生—中医学]