25种中药的体外抗毛囊蠕形螨活性筛选  被引量:7

Anti-mite Activities of 25 Kinds of Traditional Chinese Medicines for Demodex folliculorum

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作  者:田晔[1] 李朝品[1] 

机构地区:[1]安徽理工大学医学院,安徽淮南232001

出  处:《中药材》2006年第10期1013-1015,共3页Journal of Chinese Medicinal Materials

基  金:安徽省教育厅自然科学研究项目(2004kj134);安徽理工大学青年基金(DG306)

摘  要:目的:寻找体外抗毛囊蠕形螨的有效中药。方法:从中重度蠕形螨感染者面部刮取皮脂,分离毛囊蠕形螨。采用80%乙醇溶液水浴回流提取25种中药,制成200 mg/m l药液,体外用于毛囊蠕形螨。以蠕死亡时间为指标,并设立百部提取物为阳性对照药物、生理盐水为空白对照,进行体外抗螨活性筛选。结果:生理盐水作用的螨死亡时间大于120 m in;杀螨时间平均值小于5 m in的中药有黄柏、蒲公英、仙鹤草、大风子、陈皮、粉萆薢、芫花和百部,其中黄柏、蒲公英、仙鹤草、大风子、陈皮等提取物杀螨时间显著短于百部提取物(P<0.05)。结论:黄柏、蒲公英、仙鹤草等中药材具有较强的体外抗毛囊蠕形螨活性。Objective: To explore traditional Chinese medicines (TCMs) with anti-mite activities for Demodex foUiculorum in vitro. Methods: Active Demodex folliculorum were selected from patients with moderate to severe Demodex infestation. A total of 25 TCMs were individually extracted with 80% ethanol by heat under reflux, and then prepared to be concentration of 200 mg/ml. The extractions were used individually in mite-killing experiment in vitro to judge anti-mite activity by observing time of killing mites. Physiological saline and Radix Stemonae extraction were selected as blank control and positive control, respectively. Results: The TCMs with average time of killing mites below 5 min were Cortex Phellodendri, Herba Taraxac, Herba Agrimoniae, Semen Hydnocarpi, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae Hypoglaucae, Flos Genkwa and Radix Stemona. Among them, time with Cortex phellodendri, Herba Taraxac, Herba Agrimoniae, Semen Hydnocarpi and Pericarpium Cirri Reticulatae was statistically shorter than that with Radix Stemonae ( P 〈 0. 05 ). Conclusion : Cortex Phellodendri, Herba Taraxac and Herba Agrimoniae et al. had remarkable anti-mite activities to Demodex folliculorum.

关 键 词:中药 提取物 蠕形螨 杀螨 活性筛选 

分 类 号:R282.71[医药卫生—中药学]

 

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