超临界CO_2萃取广东海风藤木脂素成分工艺研究  

Study on Supercritical Carbon Dioxide Fluid Extraction Process of Lignans from Kadsura heteroclita(Roxb.) Craib

作　　者：李晓光[1] 高勤[1] 翁文[1] 罗焕敏[1] 

机构地区：[1]暨南大学药学院,广东广州510632

出　　处：《中药材》2006年第10期1096-1098,共3页Journal of Chinese Medicinal Materials

基　　金：广东省中医药管理局基金(No.1040072);广东省科技计划项目(2004B30101012)

摘　　要：目的:优化超临界CO2萃取法提取广东海风藤木脂素成分的工艺参数。方法:采用超临界CO2萃取法,分别以总木脂素含量和五味子乙素含量为指标,对萃取温度、萃取压力、粉碎粒度和CO2流量等影响因素进行考察。结果:萃取压力和粉碎粒度对总木脂素含量和五味子乙素含量的影响具有显著性意义,萃取温度和CO2流量的影响无显著性意义。结论:采用超临界CO2萃取法提取广东海风藤中木脂素成分的最佳工艺条件为:药材粉碎成细粉,萃取压力10 MPa,萃取温度45℃,CO2流量为30 L/h。Objective： To optimize supercritical carbon dioxide fluid extraction process parameters of lignans from Kadsura heteroclita （ Roxb. ） Craib. Methods： The supereritical carbon dioxide fluid extraction was adopted to extract lignans. The contents of total lignans and γ-schisandrin were determined to test the influence of pressure, temperature, grinding particle size and flow rate of CO2. Results： The extraction pressure and grinding particle size had significant effects on the content of total lignans and γ-schisandrin. However, The extraction temperature and flow rate of CO2 had no significant effect on them. Conclusion ： The optimum process parameters are as fouons： pressure is 10 MPa, temperature is 45℃. flow rate of CO2 is 30 L/h and herbs are granulated.

关 键 词：超临界CO2 广东海风藤 总木脂素 五味子乙素 正交试验 

分 类 号：R284.2[医药卫生—中药学]