氮芥联合低分子肝素治疗难治性肾病综合征的临床观察  

Effect of Chlormethine Combined with Low Moleculer Weight Heparin (LMWH) on Refractory Nephrotic Syndrome

作　　者：李英娟[1] 熊文[1] 

机构地区：[1]中南大学湘雅二医院肾内科,湖南长沙410011

出　　处：《医学临床研究》2006年第10期1559-1561,共3页Journal of Clinical Research

摘　　要：【目的】观察氮芥联合低分子肝素（LMWH）治疗难治性肾病综合征的疗效。【方法】28例难治性肾病综合征患者予盐酸氮芥静脉注射，由1mg开始，隔日注射1次，每次加量1mg，至5mg后每周注射2次，累积量达1．5～2．0mg／kg体重（约80～100mg）后停药；联合低分子肝素5000u皮下注射，1日两次。【结果】总有效率85．7％，治疗期间无严重不良反应，治疗前后尿量、尿蛋白、血浆白蛋白、总胆固醇、甘油三酯均有显著变化（P＜0．05）。伴肾功能不全者肾功能均恢复正常。【结论】氮芥联合低分子肝素治疗难治性肾病综合征安全有效。[Objective]To observe the efficacy of chlormethine combined with LMWH on refractory nephrotic syndrome（NS）. [Methods]Twenty-eight patients with refractory NS were given chlormethine injection once per two days from lmg to 5mg （1mg injection was added every time）. When the dose added to 5 mg, chlormethine was given twice per week. The treatment ended when the chlormethine reached 1.5～2.0 mg/kg （about 80～100 mg）. During the period of treatment , LMWH（5000 IU） was given twice per day. [Results]It was found that 85.7 % patients achieved clinical remission and there were no serious adverse reactions . There were significant improvement in the total volume of urine and urine protein, serum albumin, total cholesterol and triglyceride after the treatment（ P〈0.05）. The renal functions all returned to normal. [Conclusion]The combined treatment of chlormethine with LMWH is effective and safe on refractory nephrotic syndrome.

关 键 词：肾疾病综合征/药物疗法 氮芥/治疗应用 肝素 低分子量/治疗应用 

分 类 号：R692[医药卫生—泌尿科学]