残胃黏膜病变影响因素的探讨  

Influence Factors on Gastric Remnant Mucosa Lesions

作　　者：陈鸿[1] 刘芸[1] 

机构地区：[1]福建省立医院二内科,福建福州350001

出　　处：《医学临床研究》2006年第10期1611-1613,共3页Journal of Clinical Research

摘　　要：【目的】探讨幽门螺杆菌（HP）感染及胆汁反流对残胃黏膜组织损伤的影响。【方法】1999～2005年间接受胃镜检查的201例残胃病人临床资料及同期进行胃镜检查而未接受手术的对照组176例，根据胃黏膜的慢性活动性炎症、萎缩性胃炎（CAG）、肠化生（IM）、不典型增生（DYS）进行分组，结合胆汁反流、HP感染、手术方式不同等因素进行比较分析。【结果】残胃组胆汁反流发生率较对照组明显增高（P〈0．01），HP感染发生率低于对照组（P〈0．01）。有胆汁反流的残胃黏膜上述各种病变检出率较无胆汁反流组的明显增高（P〈0.05），同时存在胆汁反流和HP感染残胃黏膜损伤最为严重与无胆汁反流无HP感染残胃组比较差异有显著性（P〈0．05）。【结论】胆汁反流是残胃黏膜组织损伤的主要影响因素，同时存在HP感染对上述残胃黏膜病变的影响有协同作用。[Objective]To investigate the influence factors on gastric remnant mucosal lesions. [Methods] The pathological results of gastric remnant mucosa , HP infection and bile reflux results in 201 patients who underwent partial gastrectomy （resected group） and 176 patients at the same time （control group） from 1999～2005 were studied. HP positive rate, bile reflux, and gastric remnant mucosa lesions were compared and analyzed. [Results]The rate of HP Infection was lower in patients with remnant stomach than that in control group. The Rate of bile reflux was higher in patients of resected group than that in control group （ P〈0.01 ）, the gastric remnant mucosal lesions in patients with bile reflux, such as chronic atrophic gastritis （CAG）,intestinal metaplasia（IM） and dysplasia（DYS） were significantly more severe than those in patients without bile reflux. The mucosal lesions in the remnant stomach both of bile relfux and HP infection were most severe. [Conclusion]Bile reflux is a chief risk in gastric remnant mucosa lesions.

关 键 词：胃残端/病理学 

分 类 号：R656.61[医药卫生—外科学]