沙土鼠脑海马CA1区突触结构的衰老性变化  

Gerbil's Fading Change of Synaptic Structure in Hippocampal CA1 Sector

作　　者：刘宗良[1] 叶铮[1] 张琼珍[1] 黄素群[1] 李朗[1] 

机构地区：[1]昆明医学院解剖教研室

出　　处：《昆明医学院学报》1996年第4期4-6,共3页Journal of Kunming Medical College

基　　金：云南省科委应用基础研究基金

摘　　要：用电镜技术和体视学方法研究老年沙土鼠脑海马ＣＡ１区锥体细胞层和腔隙分子层神经毯内突触结构的变化，并与青年组相比较．结果显示：老年组较青年组锥体细胞层突触数减少２０．９４％，腔隙分子层减少１２．３２％；老年组腔隙分子层突触数密度为（０．５６８±０．０７４）／μｍ２，青年组为（０．６６３±０．０７５）／μｍ２；老年组锥体细胞层不清晰突触占该区突触总数的２６．３９％，青年组占２３．９３％．结果表明衰老时海马ＣＡ１区突触数目减少，不清晰突触代偿性增多，从而补偿了丢失突触的功能．Electron microscopy and serological quantitative method were used to examinethe synaptic structure change of the neuropil of the pyramidal cell layer and lacunosum-molecularlayer in the hippocampal CA1 area of the aged male gerbils.When compared with the younggroup,the results were illustrated as follows:the synapse number from the old group dropped by20.94% in the pyramidal cell layer and by 12.32%in the lacunosum-molecular layer;the synap-tic numerical density in the lacunocum-molecular layer was(0.568±0.074)/μm2 for the old and(0.663±0.075)/μm2 for the young;At the synaptic area the unclear synapses in the pyramidalcell layer accounted for 26.39%of the total sum in the senior group and 23.93%in the juniorgroup.In the hippocampus CA1 of the aged Gerbil,the results suggested,the synapses de-creased and the unclear synapses compensatively,making compensation for the function of the re-maining synapses.

关 键 词：沙土鼠 海马 衰老 CA1 突触结构 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学] R339.38[医药卫生—基础医学]