介电泳辅助的药物洗脱支架载药机理  

DIELECTROPHORETIC ASSEMBLY OF DRUG-LOADING NANOPARTICLES WITH DRUG-ELUTING STENTS

作　　者：朱树存[1] 易红[1] 倪中华[1] 

机构地区：[1]东南大学机械工程系,南京210096

出　　处：《机械工程学报》2006年第10期165-169,共5页Journal of Mechanical Engineering

基　　金：教育部科学技术研究(106083);江苏省自然科学基金(BK2005072;BK2006709)资助项目。

摘　　要：针对微探针型药物洗脱支架局部载药的特殊要求,提出基于介电泳自组织的载药新方法。首先根据介电泳装配原理,建立介电泳辅助的药物洗脱支架载药模型,并结合量纲一介电泳力及粒子运动控制方程,对解空间内介电泳力分布及粒子运动轨迹进行有限元模拟,讨论粒子相对电极位置及布朗运动对其装配效率的影响,在理论上证明基于介电泳装配的载药方案完全可行。最后在数值模拟的基础上,通过支架表面尖端载药测试平台,对理论预测进行了试验验证。试验结果表明:在去离子水中,当电压峰-峰值为10v,频率处于0．1～1．0MHz范围内时,直径4．4μm的乳胶颗粒在正介电泳力作用下向尖端聚集,且当频率约为500 kHz时,其粒子运动速度达到最大。A novel drug-loading method using dielectrophoretic self-organization is proposed to solve the local drug-loading of intravascular stents studded with microprobes. Based ondielectrophoretic assembly mechanism, the dimensionless dielectrophoretic force and the governing equation of motion for a particle, the drug-loading model of intravascular stems by dielectrophoresis is built for finite element analysis of the dielectrophoretic force distribution and the motion trajectories of particles in the problem space. The influence of the relative particle/electrode position and Brownian motion on the assembly efficiency is also discussed. It is proved that the assembly scheme using dielectrophoresis is feasible in theory. Finally, upon the results of the simulation, theoretical predictions of the particle response under the electric fields are experimentally confirmed by the drug-loading testing platform. Results show that for 4.4 μm latex beads suspended in de-ionized （DI） water, when the value （peak-to-peak） of the applied voltage is 10 V and the AC frequency is in the range of 0. l-1.0 MHz, the particles begin to move towards the electrodes drived by positive dielectrophoretic force, and when the AC frequency is 500 kHz, the motion rate of particle reaches the highest level.

关 键 词：纳米介电泳 载药纳米微粒 布朗运动 药物洗脱支架 

分 类 号：TP271[自动化与计算机技术—检测技术与自动化装置]