黄芪黄铜(AF)对衰老过程中小鼠胸腺组织及脑组织NO、SOD、MDA指标的影响  

THE EFFECT OF AF TO THE CHANG OF NO、SOD、MDA IN THYMUS AND BRAIN TISSUE OF SENILITY MICE

作　　者：李淑华[1] 冯芹喜[1] 刘亚威[1] 梁亿红[1] 

机构地区：[1]牡丹江医学院,157011

出　　处：《牡丹江医学院学报》2006年第5期12-14,共3页Journal of Mudanjiang Medical University

基　　金：黑龙江省中医管理局科研项目

摘　　要：目的:观察黄芪黄铜(AF)对衰老过程中小鼠胸腺组织NO、SOD、MDA含量水平的影响。方法:衰老小鼠每日尾静脉注射黄芪黄铜提取物AF,约10d。结果:给予AF后,衰老小鼠胸腺组织、脑组织NO含量升高,SOD活性增强,MDA的含量下降,与实验对照组存在显著性差异(p<0.01)。胸腺重量与对照组比较明显增加。结论:黄芪黄铜可以延缓衰老过程中小鼠胸腺的萎缩,提高机体的免疫功能,改善大脑的微循环环境,从而具有抗衰老的作用。Objective：To observe the effect of AF the Chang of nitrc oxide（ NO）, Superoxide dismutase （SOD） and malondialdehyde（MDA） in Thymus tissue and brain tissue in the senility of mice. Methods：To inject AF into vein mice tail for ten days. Results：The content of, NO ,in Thymus tissues and brain tissues was increased, SOD activity enhanced,MDA was decreased , while contrasting with control group,there was significant difference（ P 〈0.01 ）. Conclusion：AF can postpone the withering of thymus, strengthen the immunity funtion , improve microcirculation of brain tissues in the course of senility.

关 键 词：衰老 黄芪黄铜(AF) 一氧化氮(NO) 超氧化物歧化酶(SOD) 丙二醛(MAD) 

分 类 号：R285.5[医药卫生—中药学]