血清总胆汁酸在婴幼儿巨细胞病毒肝炎中的动态变化及临床意义  

Dynamic changes and clinical significance of serum total bile acid in infantile cytomegalovirus hepatitis

作　　者：刘薇[1] 蒋玉红[1] 王亚秋[1] 李伟[1] 

机构地区：[1]青岛市妇女儿童医疗保健中心检验科,山东省青岛市266011

出　　处：《世界华人消化杂志》2006年第25期2563-2565,共3页World Chinese Journal of Digestology

摘　　要：目的:探讨血清总胆汁酸(TBA)在巨细胞病毒(CMV)肝炎患儿中的动态变化和临床诊疗价值．方法:对21例CMV肝炎患儿血清TBA按照初次就诊时、入院后治疗前、治疗2 wk后、出院时进行动态检测,并与ALT和AST作比较．结果:21例CMV肝炎患儿入院治疗前TBA阳性率高于ATL阳性率(100％vs 80．9％,P<0．01):入院治疗前TBA>80μmol／L组预后不良发生率明显大于TBA≤80μmol／L组(75％vs 23．1％,P<0．01)．结论:TBA是诊断婴幼儿CMV肝炎的敏感指标,其动态检测对指导临床治疗、反映病变程度和预后判断有一定临床参考价值．AIM： To investigate the dynamic changes of serum total bile acid （TBA） in infantile cytomegalovirus hepatitis. METHODS： The levels of serum TBA in 21 infants suffered cytomegalovirus hepatitis were detected dynamically （at the first visit to a doctor, before treatment in hospital, 2 wk after treatment, and at the time leaving hospital）. Meanwhile, the results were comparatively analyzed with alanine aminotransferase （ALT） and aspartate aminotransferase （AST） levels. RESULTS： Of the 21 cases, the positive rate of TBA was significantly higher than that of ALT before treatment in hospital （100% vs 80.9%, P 〈 0.01）. The infants with TBA 〉 80 μmol/L had higher risk of unfavorable prognosis than those with TBA ≤ 80 μmol/L （75% vs 23.1%, P 〈 0.01）. CONCLUSION： TBA is a sensitive index in the diagnosis of infantile cytomegalovirus hepatitis, and dynamic inspection can help to guide the therapy, judge the severity and evaluate the prognosis of this disease.

关 键 词：婴儿 巨细胞病毒肝炎 血清总胆汁酸 动态变化 

分 类 号：R725.1[医药卫生—儿科]