硝唑尼特合成方法的改进  

The improved preparation of nitazoxanide

作　　者：李少华[1] 熊远珍[1] 匡滨海[1] 

机构地区：[1]江西医学院药学系,南昌330006

出　　处：《中国现代应用药学》2006年第5期368-369,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的用一种新的方法合成硝唑尼特并验证其结构。方法以水杨酸先制备水杨酰卤,然后与2-氨基-5-硝基噻唑反应,最后用乙酸酐成酯。结果所合成的产物结构正确,产率得到提高。结论所采用的路线切实可行。OBJECTIVE To synthesize nitazoxanide by a new way and testify its structure. METHODS First amidation then acetylation reaction was used. RESULTS The synthesized compound was correct, the yield rate was increased. CONCLUSION The method developed is adoptable.

关 键 词：合成 硝唑尼特 2-氨基-5-硝基噻唑 水杨酸 o-乙酰水杨酰氯 

分 类 号：TQ460.6[化学工程—制药化工]