^(99m)Tc-葡糖二酸显像剂的研究进展  

The advanced in ^(99m)Tc labeled glucaric acid

作　　者：张娟[1] 唐志刚[1] 王学斌[1] 

机构地区：[1]北京师范大学化学学院教育部放射性药物重点实验室,100875

出　　处：《国际放射医学核医学杂志》2006年第4期196-198,共3页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：葡糖二酸(GLA)是一种六碳二元羧酸盐的葡萄糖类似物,是葡萄糖在生物体内代谢的产物之一,存在于组织和体液中,可被99mTc标记。本文论述了GLA的制备、99mTc-GLA药盒的制备以及99mTc-GLA在心肌梗死显像和肿瘤显像中的研究进展。现有的研究结果表明,99mTc-GLA在诊断心肌梗死和某些肿瘤(如乳腺癌)表现了良好的性质,因此是一种很有应用前景和研究价值的显像剂。Glucaric acid （GLA） is a six-carbon dicarboxylic acid sugar, one of the natural endogenous end-eatabolite of glueose, whieh is normally present in tissues and body fluids. It ean be labeled with ^99mTc. In this review we diseuss the synthesis of GLA and the investigation of ^99mTc-GLA inelude the preparation of the kit, myocardiol infarction imaging and some tumor imaging （espeeially in breast tumor imaging）. All the researches suggest that ^99mTc-GLA is a potential imaging for myocardiol infarction imaging and tumor imaging.

关 键 词：葡糖二酸 锝-99m 药盒 心肌梗死 乳腺肿瘤 

分 类 号：R817[医药卫生—影像医学与核医学]