伊贝沙坦对早期糖尿病肾病患者尿转化生长因子β_1的影响  

THE INFLUENCE OF IRBESARTAN ON URINARY TRANSFORMING GROWTH FACTOR-β_1 IN EARLY DIABETIC NEPHROPATHY

作　　者：冯毅[1] 粱干雄[1] 

机构地区：[1]中山市人民医院,广东中山528400

出　　处：《现代医院》2006年第11期16-17,共2页Modern Hospitals

摘　　要：目的观察血管紧张素Ⅱ受体拮抗剂(ARB)伊贝沙坦对早期糖尿病肾病患者尿转化生长因子β1(TGF-β1)排泄的影响,探讨其治疗糖尿病肾病的可能机理。方法72例早期糖尿病肾病患者被随机分为对照组(n=34)和伊贝沙坦组(n=38),治疗12周后测定两组治疗前后尿白蛋白排泄率(UAER)、尿TGF-β1的水平。结果伊贝沙坦组UAER、尿TGF-β1水平均有明显下降。结论伊贝沙坦对糖尿病肾病有保护作用,其机理可能与下调肾脏局部尿TGF-β1水平有关。Objective To observe the influence of irbesartan on urinary transforming growth factor - betal （ TGF - β1 ） in early diabetic nephropathy and explore their therapeutic mechanism. Methods Seventy - tow type 2 diabetic patients with early diabetic nephropathy were randomly divided into control group and irbesartan treatment group. Urinary albumin excretion and urinary TGF - β1 was measured. Results Urinary albumin excretion and urinary TGF - β1 levels in irbesartan treatment group were significantly decreased after 12 weeks treatment. Conclusion Irbesartan have renoprotective effect in patients with early diabetic nephropathy. The decrease of TGF - β1 concentration in renal tissue may be a mechanism for this action.

关 键 词：糖尿病肾病 转化生长因子Β1 伊贝沙坦 

分 类 号：R654.2[医药卫生—外科学]