子痫孕妇胎盘瘦素水平测定及其意义  

Clinical significance of lepton in placento of patients with eclampsia

作　　者：周立岩[1] 张正惠[1] 李美杰[1] 

机构地区：[1]青岛市第八人民医院妇产科,山东266100

出　　处：《中国生育健康杂志》2006年第5期283-285,共3页Chinese Journal of Reproductive Health

摘　　要：目的检测子痫各期孕妇胎盘瘦素的水平,探讨瘦素在子痫发病中的作用。方法用免疫组织化学检测49例子痫各期孕妇(其中轻度子痫前期17例,重度子痫前期18例,子痫14例)及40例正常妊娠孕妇胎盘瘦素的水平;同时观察子痫各期孕妇胎盘瘦素水平与血压之间的相关关系。结果子痫孕妇胎盘瘦素水平明显高于正常妊娠妇女,差异有统计学意义(P<0.01),而子痫孕妇组中子痫期孕妇胎盘瘦素水平又显著高于轻、重度子痫前期妇女,差异有统计学意义(P<0.05);子痫孕妇组胎盘瘦素水平与收缩压、舒张压、平均动脉压呈正相关性,相关系数分别为0.313,0.412,0.402(P<0.05)。结论胎盘瘦素水平在子痫孕妇组明显升高,胎盘瘦素水平的升高可能成为子痫发病的重要机制。Objective To investigate the placental leptin in eclampsia patients and normal pregnancies and to study its clinical significance. Methods SABC （strept avidin-biotin complex） was used to measure the levels of leptin in 49 patients with eclampsia （17 mild pre-eclampsia, 18 severe pre-eclampsia and 14 eclampsia） and 40 normal pregnant women. Results The mean placental leptin in eclampsia wowen was significantly higher than that in normal pregnant women （P〈0.01）. The placental leptin level was markedly higher among eclampsia women than among preeclampsia women （P〈0.05）. The placental leptin was positively correlated with the levels of systolic blood pressure （SBP）, diastolic blood pressure （DBP） and mean arterial pressure （MAP）, r=0. 313, 0. 412, 0. 402 （P〈0.05） respectively. Conclusion The level of placental leptin increases among eclampsia patients. This might play an important role in pathogenesis of eclampsia development.

关 键 词：子痫 妊娠高血压综合征 胎盘瘦素 

分 类 号：R714.245[医药卫生—妇产科学]