硝唑尼特抗免疫抑制小鼠隐孢子虫活性试验  

Anticryptosporidial Activity of Nitazoxanide in an Immunosuppressed Mice Model

作　　者：张可煜[1] 郑姣妹[1] 王权[1] 薛飞群[1] 

机构地区：[1]中国农业科学院上海兽医研究所农业部畜禽寄生虫学重点开放实验室,上海200232

出　　处：《动物医学进展》2006年第10期58-61,共4页Progress In Veterinary Medicine

基　　金：上海市科技兴农重点攻关项目(2000-6-02)

摘　　要：研究硝唑尼特抗隐孢子虫的活性,采用地塞米松抑制昆明鼠免疫功能,经口接种感染微小隐孢子虫孢子化卵囊,成功制备出微小隐孢子虫感染的动物模型。将感染微小隐孢子虫的小鼠随机分为感染对照组以及高、中、低剂量3个药物剂量组,连续经口灌服硝唑尼特治疗1周,观察每只小鼠每天排出微小隐孢子虫卵囊的数量,以感染抑制率来评价硝唑尼特抗微小隐孢子虫的活性。结果表明,200 mg/(kg.d)剂量组能显著减少小鼠排出隐孢子虫卵囊的数量,对治疗微小隐孢子虫感染具有较好的疗效。To study the anticryptosporidial activity of nitazoxanide in an immunosuppressed mice model for cryptosporidiosis, the Kunmin mice being immunosuppressed with dexamethasone were successfully infected by the Uryptosporidium parvum sporulated oocysts. The infected mice were divided into control, groups of high, middle and low doses of the drug, and their oocyst shedding intensities were observed everyday. The drug treatments lasted for one week and the activities of the drug were evaluated by the infection restraint rates. The experimental results showed the treatment with 200 mg/kg bodyweight significantly inhibited oocyst excretion, so the drug was effective for cryptosporidiosis.

关 键 词：隐孢子虫 硝唑尼特 免疫抑制小鼠模型 

分 类 号：S859.795[农业科学—临床兽医学] S852.723[农业科学—兽医学]