自制速凝止血敷料对犬上矢状窦破裂出血的止血作用  

Hemostatic effects of a self-designed rapid-hemostatic-dressing on bleeding of partially ruptured superior sagittal sinus in dogs

作　　者：杨治荣[1] 卢亦成[2] 侯立军[2] 白如林[2] 

机构地区：[1]上海交通大学附属第六人民医院脑创中心,上海200233 [2]第二军医大学长征医院神经外科上海市神经外科研究所,上海200003

出　　处：《第二军医大学学报》2006年第10期1131-1133,共3页Academic Journal of Second Military Medical University

基　　金：全军"十五"重点课题(01Z062).~~

摘　　要：目的:评价速凝止血敷料对犬静脉窦破裂出血的止血效果。方法:采用枪伤结合手术的方法建立犬上矢状窦破裂出血模型(n=15),15只犬分为2组,速凝止血敷料组和即速纱对照组,分别应用自行研制的速凝止血敷料(n=10)和即速纱(n=5)进行止血,观察比较止血1 h后两组的存活时间、出血量及血液学参数。结果:成功建立犬上矢状窦破裂出血模型。速凝止血敷料组止血1 h后犬血液学参数与制模前无显著差异,且存活时间明显长于即速纱对照组(P<0.05),出血量明显少于即速纱对照组(P<0.05)。结论:速凝止血敷料对犬上矢状窦破裂出血止血满意,是一种良好的止血敷料。Objective：To evaluate hemostatic effects of a self-designed rapid-hemostatic-dressing （RHD） on bleeding ot the partially ruptured superior sagittal sinus in dogs. Methods： Bleeding models of the partially ruptured superior sagittal sinus were established in 15 dogs by gunshot and surgery. The 15 model dogs were divided into 2 groups： RHD group （n=10） and control group （treated with surgicel, n=5）. The survival time, blood loss, and other hematological parameters were measured over a 1- hour period. Results： The bleeding models of the partially ruptured superior sagittal sinus were successfully established in dogs. There were no significant differences in the baseline parameters of dogs compared with those 60 minutes after RHD treatment. The survival time in RHD group was significantly longer than that in control group and the blood loss was significantly lower than that of the control group （both P〈0.05）. Conclusion： RHD has satisfactory hemostatic effects on partially ruptured superior sagittal sinus in dogs, indicating it is an excellent hemostatic dressing.

关 键 词：上矢状窦 破裂 止血 敷料 

分 类 号：R651.15[医药卫生—外科学]