甘康对小鼠免疫性肝损伤的保护作用  

Protective effects of Gankang on immunological liver injury in mice

作　　者：王迪生[1] 高继君[1] 张承光[1] 项雷[1] 杨青杨[1] 邢亚群[1] 岑德意[2] 董六一[2] 陈志武[2] 

机构地区：[1]蚌埠医学院第二附属医院,蚌埠233040 [2]安徽医科大学药理教研室,合肥230032

出　　处：《安徽医科大学学报》2006年第5期544-546,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的探讨甘康对小鼠免疫性肝损伤的保护作用及可能机制。方法建立BCG+LPS诱导免疫性肝损伤小鼠模型,用分光光度法检测血清中ALT、AST水平和肝匀浆、GSH-px、SOD含量。结果甘康(200、400和800mg/kg×10d)灌胃给药均能降低血清中升高的转氨酶水平,减轻肝组织坏死范围及程度,减少炎细胞浸润,使升高的肝指数降低,甘康还可降低肝匀浆MDA含量,使降低的肝匀浆GSH-px、SOD活性升高。结论甘康对免疫性肝损伤具有保护作用,其机制与其抗氧化活性等有关。Objective To investigate the effects of Gankang on immunological liver injury in mice. Methods The model of immunological liver injury in mice was produced by injection of Bacillus Calmette Guerin （BCG） and lipopolysaccharide（LPS） from tail vein. The levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST） in serum, malondiadehyde（MDA） content, superoxide dismutase（SOD） and glutathione peroxidase（ GSH- px） activities in liver homogenate were assayed by spectrophotometry. Results Gankang （200,400, 800 mg/kg） significantly decreased levels of serum transaminase （ ALT, AST） and liver index, attenuated the area and extent of necrosis and reduce the infiltration of inflammatory cells. Furthermore, Gankang also decreased MDA content and prevented the reduction of SOD and GSH-px activities in liver homogenate. Conclusion Gankang shows significant protective action on immunological liver injury in mice.

关 键 词：甘康 免疫性肝损伤 机制 

分 类 号：R282.71[医药卫生—中药学]