叶酸和维生素B_(12)治疗某烟厂工人支气管鳞状化生  

A study on folic acid and Vit B_(12) in the treatment of bronchial squamous metaplasia in a cigarette factory

作　　者：胡杰贵[1] 祝杨[1] 杨晓春[1] 吴继峰[2] 王勇[3] 

机构地区：[1]安徽医科大学第一附属医院呼吸内科,合肥230022 [2]安徽医科大学病理教研室,合肥230022 [3]安徽医科大学附属省立医院肿瘤科,合肥230022

出　　处：《安徽医科大学学报》2006年第5期589-590,共2页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅科研基金资助(编号:941017)

摘　　要：目的 探讨应用叶酸（FA）和维生素（Vit）B12治疗支气管黏膜重度鳞状化生的可行性。方法 将经痰涂片诊断的56例重度鳞状化生患者随机分为治疗组和对照组，治疗组口服FA和VitB12，持续6个月；对照组服用安慰剂治疗6个月，治疗前、后检测血清FA、VitB12浓度。细胞学异型程度用0～3的等级表示。结果 两组在治疗前的细胞异型程度均为3，血清FA、VitB12浓度比较差异无显著性；治疗后治疗组细胞异型程度均值为1．22，治疗前后比较差异有显著性（P〈0．05），而对照组均值为2．4，治疗前后比较差异无显著性。血清FA、VitB12浓度也有类似结果。结论 FA和VitB12对鳞状化生有治疗作用。Objective To elucidate the possibility of treating severe bronchial squamous metaplasia with FA and Vit B12. Methods 56 cases of severe bronchial squamous metaplasia identified using sputum smear were randomly divided into two groups . FA 15mg and Vit B12 1.5 mg were administered daily for 6 months for the trial group, while the other used placeboes. The grade of cellular atypia was measured on sputum smear using a scoring system from 0 to 3. Results There were no significant differences between two groups in the scores and the serum FA,Vit B12 at the beginning. The trial group showed significant decrease of the scores, increase of the serum FA, Vit B12, while the control group did not, which showed statistical difference （/9 〈0.05）. Conclusion Bronchial squamous metaplasia could be treated with FA and Vit B12.

关 键 词：叶酸/治疗应用 维生素B12/治疗应用 化生 

分 类 号：R977.22[医药卫生—药品] R977.4[医药卫生—药学]