糖尿病肾病肾功能不全优化防治方案研究的统计分析  

Statistical analysis of data gained from study on project of treating and preventing diabetic nephropathy renal inadequacy

作　　者：白云静[1] 申洪波 赵进喜[3] 王连心[1] 赵世初[1] 孟庆刚[1] 

机构地区：[1]北京中医药大学,北京100029 [2]中国中医药科技开发交流中心,北京100027 [3]北京中医药大学东直门医院,北京100700

出　　处：《北京中医药大学学报》2006年第9期631-634,640,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.90409005);国家中医药管理局资助项目(No.02-03LP15);国家"十五"攻关项目(No.2001BA701A13c)

摘　　要：目的探讨统计分析方法在中医疾病及证候疗效评价研究中的合理应用问题。方法应用Kruskal-Wallis秩和检验、Ridit分析、一元和多元方差分析等方法对糖尿病肾病肾功能不全优化防治方案研究所得到的资料进行统计分析。结果中医组和中西组证候疗效、证候总积分均优于西药组;中医组在疾病综合疗效、降低血清肌酐、升高内生肌酐清除率、改善肾功能方面优于中西组和西医组,中西组和西医组上述方面无显著性差异。结论中医辨证治疗是糖尿病肾病肾功能不全代偿期比较优化的治疗方案;合理应用统计分析方法是进行中医疾病及证候疗效评价研究的重要环节。Objective To investigate proper application of statistics on curative effect evaluation of disease and syndrome of TCM. Methods Kruskal-Wallis rank test, Ridit analysis, univariateANOVA and MANOVA were used to analysis the data gained according to the project of treating and preventing diabetic nephropathy renal inadequacy. Results The curative effects and total syndrome integral of both the chinese herbs treated group and the integrated Chinese and western medicine treated group were better than that of the western medicine treated group. The chinese herbs treated group had better results in general curative effect, serum Cr reducing, CCr enhancing and renal function improving than the other tow groups. There was no notable difference between the integrated Chinese and western medicine treated group and the western medicine treated group in the above-mentioned aspects. Conclusion Treatment according to syndrome differentiation is the optimized therapy scheme for diabetic nephropathy renal inadequacy. Applying methods of statistics properly is the key link in the study on curative effect evaluation of disease and syndromes of TCM.

关 键 词：糖尿病肾病肾功能不全 临床研究 统计分析 

分 类 号：R269.25[医药卫生—中西医结合]