结缔组织生长因子在慢性乙型肝炎和肝硬化中的表达研究  

Study on the relationship between expression of connective tissue growth factor and chronic hepatitis B or posthep-atitic cirrhosis.

作　　者：汪明明[1] 崔速南[1] 李新立[1] 杨公炜[1] 杜文军[1] 

机构地区：[1]济南市传染病医院肝病科,山东济南250021

出　　处：《临床肝胆病杂志》2006年第5期361-362,共2页Journal of Clinical Hepatology

摘　　要：探讨结缔组织生长因子(CTGF)的肝内表达与肝炎肝硬化的关系。62例慢性乙肝或肝炎肝硬化的肝组织活检标本,采用免疫组化进行CTGF肝内表达研究。肝炎肝硬化患者CTGF的肝内表达明显高于慢性乙肝患者(P<0．01),慢性乙肝炎性活动期患者CTGF的表达高于非活动期患者(P<0．05)。CTGF的表达主要集中于汇管区和纤维化区,肝星状细胞、成纤维细胞和窦状隙内皮细胞染色常呈阳性。CTGF的表达与肝硬化密切相关,肝细胞的炎性活动可加强CTGF的表达。肝星状细胞、成纤维细胞和窦状隙内皮细胞是肝内CTGF的重要来源。To explore the relationship between the expression of connective group tissue growth （CTGF） and posthepatitic cirrhosis. The expression of CTGF in hepatic biopsy samples from sixty two cases with chronic hepatitis B or posthepatitie cirrhosis were studied by immunohistochemical staining. Expression level of CTGF in cirrhosis group was closely related to fibrosis degree （ P 〈0. 01 ） and with activity of chronic hepatitis B （ P 〈0. 05 ）. CTGF was mainly expressed in portal tracts and fibrotic areas. Positive staining was observed in hepatic stellate cells, sinusoidal endothelial cells and fibroblasts. There was a significant association between CTGF intensity and liver fibrosis. It can be concluded that CTGF was mainly produced in hepatic stellate cells, sinusoidal endothelial cells and fibroblasts.

关 键 词：结缔组织生长因子 肝内表达 慢性乙肝 免疫组化染色 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]