转移抑制基因nm23 mRNA表达水平与非小细胞肺癌临床病理特征及预后的关系  

Relationship between mRNA expression of metastasis suppressor gene nm23 and clinicopathological features and prognosis of non small cell lung carcinoma

作　　者：王海峰[1] 陈晓峰[1] 丁嘉安[1] 高文[1] 周逸鸣[1] 陈乾坤[1] 

机构地区：[1]上海市肺科医院胸外科,上海200433

出　　处：《肿瘤》2006年第10期920-923,共4页Tumor

基　　金：上海市卫生局科技发展基金(编号:99424)

摘　　要：目的:研究非小细胞肺癌中nm23 mRNA表达水平与肺癌临床病理特征及预后之间的关系。方法:53例肺癌标本,44例(癌旁)正常肺组织,用RT-PCR方法检测标本中nm23 mRNA的表达水平,根据手术、病理和影像学结果判断有无转移并确定分期,就nm23 mRNA表达水平与临床变量之间进行分析。结果:nm23 mRNA在肺癌和(癌旁)正常肺组织中的表达阳性率分别为43．4％(23／53)和40．9％(18／44),P>0．05;在低分化、晚期、肺门纵隔淋巴结转移的非小细胞肺癌中,其nm23 mRNA的表达量显著降低(P<0．05),nm23 mRNA表达阳性和阴性的患者中位生存期分别为43个月和46个月,其表达量与患者的预后之间未发现显著相关性(P>0．05)。结论:nm23 mRNA的表达与肺癌的分化、转移及病理分期有关,但尚无足够证据显示其与肺癌的预后有相关关系。Objective： To investigate the relationship between the expression level of nm23 mRNA and the pathoclinical characteristics and the prognosis of patients with non-small cell lung carcinoma （NSCLC）. Methods： We collected 53 specimens of NSCLC, 44 specimens of para-cancer normal lung tissues. The expression level of nm23 mRNA was measured by RT-PCR. The tumor stage was determined according to the results of surgery, pathological examination, and imaging diagnosis. Then analyses were carried out between the level of nm23 mRNA expression and the clinical variables. Results：The positive-rate of nm23 mRNA expression were 43.4% （23/53） and 40.9% （18/44） in specimens of lung cancer and para-cancer normal lung tissues, respectively （P〉0.05）. The expression level of nm23 mRNA was significantly decreased in low-differentiated, advanced, and mediastinal lymph node-metastatic NSCLC tissues （P〈0.05）. The median survival times were 43 months and 46 months for nm23-positive and nm23-negative patients, respectively. But expression level of nm23 had no significant correlation with the prognosis of patients （P〉0.05）. Conclusion： The expression level of nm23 mRNA is related to the differentiation, metastasis, and pathological stage of lung cancer. There were no enough evidence demonstrating that nm23 expression correlated with the prognosis of patients.

关 键 词：肺肿瘤 癌 非小细胞肺 基因表达 基因 nm23 

分 类 号：R734.2[医药卫生—肿瘤]