Study on the preparation and biodistribution of ^(99m)Tc-HMIBP  

作　　者：GUO Xue-Hua LUO Shi-Neng WANG Hong-Yong ZHOU Lian XIE Min-Hao YE Wan-Zhong YANG Min WANG Yang 

机构地区：[1]School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China [2]Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China

出　　处：《Nuclear Science and Techniques》2006年第5期285-288,共4页核技术（英文）

摘　　要：99mTc-HMIBP, a new bone-imaging agent, was prepared by the reduction of 99mTc-pertechnetate in the presence of SnCl2?2H2O. The effects of the amounts of SnCl2?2H2O and HMIBP and the pH value on the labeling yield and radiochemical purity of 99mTc-HMIBP were investigated. When the amounts of SnCl2?2H2O and HMIBP were more than 10 μg and 2.5 mg, respectively, the pH value was between 2 and 7, and the labeling reaction contin- ued for 10 min, both labeling yield and radiochemical purity of 99mTc-HMIBP were more than 90%. The biodistribu- tion in rats and bone scan in rabbits were also studied. The results showed that the bone uptake is up to 7.94%ID/g at 30 min after injection of 99mTc-HMIBP, bone-to-muscle and bone-to-blood uptake ratios were 20.89 and 16.89, re- spectively. The clear bone image was obtained at 120 min after injection of 99mTc-HMIBP and clearance in soft tissue was visible. All of the above-mentioned results suggested that 99mTc-HMIBP may be a potential bone-imaging agent.^99mTc-HMIBP, a new bone-imaging agent, was prepared by the reduction of ^99mTc-pertechnetate in the presence of SnCl2·2H2O. The effects of the amounts of SnCl2·2H2O and HMIBP and the pH value on the labeling yield and radiochemical purity of ^99mTc-HMIBP were investigated. When the amounts of SnCl2·2H2O and HMIBP were more than 10 μg and 2.5 mg, respectively, the pH value was between 2 and 7, and the labeling reaction continued for 10 min, both labeling yield and radiochemical purity of ^99mTc-HMIBP were more than 90%. The biodistribution in rats and bone scan in rabbits were also studied. The results showed that the bone uptake is up to 7.94%ID/g at 30 min after injection of ^99mTc-HMIBP, bone-to-muscle and bone-to-blood uptake ratios were 20.89 and 16.89, respectively. The clear bone image was obtained at 120 rain after injection of ^99mTc-HMIBP and clearance in soft tissue was visible. All of the above-mentioned results suggested that ^99mTc-HMIBP may be a potential bone-imaging agent.

关 键 词：骨显影剂 体内分解 ^99MTC 放射医学 

分 类 号：R817[医药卫生—影像医学与核医学] R981[医药卫生—放射医学]