普伐他汀改善冠心病合并高血压患者脉压的疗效  

Effect of pravastatin on improvement of pulse pressure in patients of coronary artery disease and hypertension

作　　者：宗刚军[1] 周辽军[1] 吴刚勇[1] 陈景开[1] 

机构地区：[1]解放军第101医院心内科,江苏无锡市214044

出　　处：《心血管康复医学杂志》2006年第5期480-482,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察普伐他汀对冠心病合并高血压病患者降压治疗时脉压的影响。方法:选择42例正在规则服用降压药物治疗并且脉压≥60 mmHg的冠心病合并高血压病患者,随机分为对照组(21例)和普伐他汀组(21例),两组均给予冠心病、高血压病常规药物治疗,普伐他汀组加用普伐他汀(20 m g/d),对照组不加用其他药物,均治疗3个月。观察治疗前、后肱动脉血压、心率,以及脉压,血清C-反应蛋白等指标。结果:对照组治疗后脉压没有明显的变化,普伐他汀组肱动脉收缩压、脉压有明显的降低(P<0.05),而舒张压和心率没有明显的变化,同时发现普伐他汀组治疗后血清C-反应蛋白水平有明显的降低(P<0.05)。结论:普伐他汀能够降低冠心病合并高血压病患者的脉压和炎症反应。Objective： To investigate the effect of pravastatin on pulse pressure in patients with coronary artery disease and hypertension. Methods： Forty-two patients with pulse pressure ≥60 mmHg were divided into control group （n =21, treated with routine therapy） and pravastatingroup [n=21, treated with routine therapy and pravastatin （20 mg, daily for 3 months）]. Systolic blood pressure, diastolic blood pressure, heart rate, pulse pressure, serum C— reaction protein were measured before and after treatment. Results ： No change of all indexes was found after treatment in control group. In pravastatin group, the systolic blood pressure and pulse pressure decreased significantly （P〈0. 05）, the level of C—reaction protein decreased （P〈0. 05） but diastolic pressure and heart rate no change after treatment. Conclusion： Pravastatin may reduce pulse pressure and inflammatory reaction.

关 键 词：普伐他汀 冠状动脉疾病 高血压 

分 类 号：R541.4[医药卫生—心血管疾病]