呱氨托美汀的镇痛作用及其部分作用机制研究  

The analgesic effect of amtolmetin guacyl and its mechanism of action

作　　者：李元海[1] 李俊[1] 黄艳[1] 吕雄文[1] 金涌[1] 

机构地区：[1]安徽医科大学药学院

出　　处：《安徽医药》2006年第11期806-808,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的 探讨呱氨托美汀的镇痛作用及其作用机制。方法 利用小鼠福尔马林试验和冰醋酸扭体试验，观察AMG的镇痛效果。应用MDA、SOD、GSH-PX试剂盒，测定冰醋酸扭体试验小鼠血清MDA含量、SOD、GSH-PX活性，研究AMG镇痛作用的机制。结果 AMG（240，120，60mg·kg^-1）灌胃给药60min后对小鼠福尔马林致痛模型的Ⅱ相（15—30min）具有显著的镇痛作用；AMG（240，120，60mg·kg。）灌胃给药30min和60min后明显减少小鼠AA扭体次数，增加镇痛抑制率，对小鼠AA扭体致痛模型具有明显的镇痛作用，并且随剂量增加镇痛作用增强。AMG降低小鼠AA扭体致痛模型的血清MDA含量，增加其SOD活性。结论呱氨托美汀具有较强的镇痛作用，可能与其抑制氧自由基生成和抗氧化作用有关。Aim To investigate the analgesic effect of amtolmetin guacyl and its mechanism of action in mice. Methods The writhing test and the formalin test were performed in order to study the analgesic effect of AMG, The kits of malondialdehyde （ MDA）, superoxide dismutase（SOD） and glutathione peroxidase （GSH-PX） were used to determine the MDA content,SOD and GSH-PX activities of mice＇s serum in the writhing test for the researches on mechanism of analgesic effect. Results AMG demonstrated significant analgesic effect in the formalin test （second phase 15 ~ 30 min） at 60 min after AMG（240,120,60 mg · kg^-1） were intragastrically administered in the mice. AMG significantly reduced number of writhing at 30 min and 60min after AMG（240,120,60 mg kg^-1 ） were intragastrically administered in the mice. AMG had significant analgesic effect on mice of writhing test. Moreover the intensity of analgesic effect rose as the increase in dose. AMG significantly decreased in the MDA content of serum and increased in SOD activities of serum in the writhing test. Conclusion These data indicate that amtolmetin guacyl has significant analgesic effect, and that its mechanism of action seems to be relative to inhibition the free radical from producing and antioxidation.

关 键 词：镇痛 呱氨托美汀 非甾体抗炎药 

分 类 号：R96[医药卫生—药理学]