吸毒人群HAV和HEV重叠感染状况及其影响因素分析  

Analysis on Superinfection and Influencing Factors of HAV/HEV Among Drug Abusers

作　　者：李成华[1] 黄民主[2] 谭梅娟[2] 陈伟[2] 关岚[2] 刘浩[2] 李登清[3] 戴卫平 张琰[2] 

机构地区：[1]湖南省安仁县疾病预防控制中心,湖南安仁423600 [2]中南大学湘雅公共卫生学院 [3]中南大学医学技术与情报学院 [4]长沙市新开铺戒毒所

出　　处：《实用预防医学》2006年第5期1184-1186,共3页Practical Preventive Medicine

摘　　要：目的了解吸毒人群中HAV、HEV重叠感染状况及其影响因素。方法现况研究,整群抽样法抽取某女性戒毒所和某男性戒毒所中吸毒人员596名,收集有关资料并采集血清标本。用酶联免疫吸附试验(ELISA)检测血清中抗-HAVIgG及抗-HEVIgG,采用Chi-square检验和Logistic回归分析对数据进行统计学处理。结果抗-HAVIgG及抗-HEVIgG均为阳性者22例,重叠感染率3.69%(22/596)。经χ2检验,不同年龄(χ2=2.605,P=0.272)、不同文化程度(χ2=1.974,P=0.160)、是否饮用生水(χ2=0.460,P=0.497)、家庭成员有无肝炎病史(χ2=2.008,P=0.156)的HAV、HEV重叠感染率差异无显著性。经Logistic回归分析,年龄(OR=1.72)、文化程度(OR=2.29)、家庭成员肝炎病史(OR=2.08)与吸毒者HAV、HEV重叠感染相关。结论吸毒人群是HAV、HEV重叠感染的高危人群,年龄增大、文化程度低、家庭成员肝炎病史可能是吸毒人群中HAV、HEV重叠感染的危险因素。Objective To study the condition of superinfection of HAV/HEV among drug abusers and the risk factors. Methods By a cross- sectional study, we recruited 596 cases from a female and a male drug- relief reformatory. A structured questionnaire was designed to obtain the drug abusers＇ information. After the interview, serum samples were collected and ELISA was applied to assess the anti - HAV IgG and anti - HEV IgG of the samples. Data were analyzed by Ohi-square test and Logistic regression. Results Superinfection of HAV/HEV was identified in 22 cases （3.69%） of 596 drug abusers. Ohi- square analysis showed that the difference of superinfection rate of HAV/HEV was not significant among different age grouP（x^2 = 2. 605, P = 0. 272）, different educational level（x^2= 1. 974, P = 0. 160）, different drinking water（x^2 = 0.460, P = 0.49？） and different family history of hepatitis（x^2 = 2. 008, P = 0. 156）. Logistic regression analysis that the risk factors of the superinfection of HAV/HEV were age （ OR = 1. 72 ）, educational level （OR = 2.29 ） and family history of hepatitis （OR = 2.08）. Conclusion The drug abusers are the high - risk population for HAV/HEV superinfection. Age, low educational level and family history of hepatitis are the risk factors of HAV/HEV superinfection.

关 键 词：流行病学 吸毒 甲型肝炎 戊型肝炎 重叠感染 酶联免疫吸附试验 

分 类 号：R373.21[医药卫生—病原生物学]