铅和乙醇对雄性大鼠生殖系统的联合毒作用  

Study of collaborating effect of lead and ethanol on reproductive function in male rats

作　　者：谭成森[1] 靳翠红[1] 刘秋芳[1] 赵剑[1] 蔡原[1] 

机构地区：[1]中国医科大学公共卫生学院毒理教研室,辽宁沈阳110001

出　　处：《中国工业医学杂志》2006年第5期286-287,共2页Chinese Journal of Industrial Medicine

摘　　要：采用整体动物实验方法,观察铅和乙醇对大鼠精子数量和质量,以及血中性激素水平的联合作用。结果显示,精子计数联合组比铅和乙醇单独作用组显著减少;精子活动度分析联合组与其他各组比较显著下降。铅和乙醇单独作用均可使雄性大鼠血清睾酮(T)升高,促黄体生成激素(LH)下降,联合作用使T降低,LH较单独作用组升高。提示铅和乙醇联合染毒对雄性大鼠生殖毒性影响可能具有增毒作用。Rats were used to observe the effect of lead and ethanol on the quantity and quality of sperms and the levels of sex hormones in the study. The results showed that sperm counts in lead or ethanol administrated group were ,all decreased compared with control rats, the sperm count in lead-ethanol collaborating exposure group was much lower than that of lead or ethanol group. The motility of sperm in collaborating exposure group was also obviously decreased compared with lead or ethanol group. Additionally, the sex hormones determination also revealed that lead or ethanol might induce a marked decline of sermn testosterone （T） level and a definite increase of sermn luteinizing hormone （LH） level, whereas collaborating exposure of lead and ethanol showed some adverse effect on sermn T and LH levels. It is suggested that the combining exposure of lead and ethanol might produce some additive effect in reproduction toxicity in male rats.

关 键 词：铅 乙醇 精子 性激素 

分 类 号：R994.6[医药卫生—毒理学] R114[医药卫生—药学]