不完全系统性红斑狼疮患者的随访研究及病情进展预测(英文)  

Clinical outcome and predictors of disease evolution in patients with incomplete systemic lupus erythematosus

作　　者：李博[1] 叶志中[1] 庄俊汉[1] 汪迅[1] 张丽君[1] 李剑松[1] 

机构地区：[1]深圳市四人民医院香蜜湖风湿病分院

出　　处：《中国现代医学杂志》2006年第19期2884-2887,共4页China Journal of Modern Medicine

基　　金：Shenzhen key projects foundation assistance (No.2005C10)

摘　　要：目的观察不完全系统性红斑狼疮(ILE)患者的临床随访研究结果,探索其病情进展预测因素。方法对ILE患者定期随访,记录其临床资料及实验室检查结果,随访结束时分析病情进展预测因素。结果共有19例ILE患者入选本项研究。在3年的随访研究中,有11例ILE患者发展为SLE。危险因素分析显示颧部红斑、光过敏、抗dsDNA抗体阳性与SLE进展相关。结论在本次随访研究中,虽有58%的ILE患者最后进展为SLE,但所有患者的SLEDAI分值都较低,提示ILE为狼疮的一种比较轻的亚型。颧部红斑、光过敏及抗ds-DNA抗体阳性预示这些患者可能发展为SLE.[Objective] To describe the outeome and identify risk factors for evolution into complete systemic lupus erythematosus （SLE） within the population of incomplete lupus erythematosus （ILE）. [Methord] Clinical and serologic manifestations of these patients were recorded in standardized formats and all patients were evaluated annually. [Results] Nineteen patients with ILE were included, during follow-up, eleven patients developed complete SLE. Hazard analyses showed that malar rash, photosensitivity and elevated anti-dsDNA were associated with SLE occurrence. [Conclusions] In this follow-up study of patients with ILE, 58% of ILE patients developed complete disease, but the SLEDAI score of all patients were very low, which suggested that ILE represents a mild spectrum of luous. Malar rash, ohotosensitivity and elevated anti-dsDNA were nredietors of eomolete SLE.

关 键 词：系统性红斑狼疮 不完全系统性红斑狼疮 临床结果 危险因素 

分 类 号：R691[医药卫生—泌尿科学]