轻稀土元素抑癌作用机理研究  

Studies on tumor suppression mechanism of light rare earth elements

作　　者：纪云晶 肖白[1,2,3,4] 王宗惠 崔明珍 吕有勇[1,2,3,4] 

机构地区：[1]北京市劳动卫生职业病防治研究所 [2]首都医科大学附属北京红十字朝阳医院 [3]北京医科大学临床肿瘤学院 [4]北京市肿瘤防治研究所

出　　处：《卫生毒理学杂志》1996年第4期223-227,共5页Journal of Health Toxicology

基　　金：国家攀登计划资助

摘　　要：以体外培养的人胃癌细胞ＰＡＭＣ８２和人白血病细胞Ｋ５６２为研究对象，观察了轻稀土元素对癌细胞在软琼脂中生长能力、细胞骨架微管和微丝、钙调素水平及相关抑癌基因表达的影响。轻稀土元素可使癌细胞微管结构发生类似正常细胞的转变，在软琼脂中的生长能力下降，癌细胞内钙调素水平下降，抑癌基因ｐ５３、ｐ１６和ｐ２１表达水平上升。Studies on the tumor suppression mechanism of light rare earth elements (RE) are reported. The results showed that human gastric cancer cell line PAMC82 treated by RE chloride decreased colony forming ability on soft agar culture and the cell microtubule structure exhibited changes similar to normal cells. The calmodulin (CaM) levels were decreased in human leukemia cells (K 562 ) treated with cerium chloride and neodymium chloride. The northern blot analysis revealed marked up regulation of p53, p16(MTS1), p21(WAF1) gene expressions in PAMC82 cells treated with lanthanum chloride and cerium chloride, as compared to parent PAMC82. \ \

关 键 词：轻稀土 细胞分化 钙调素 抑癌作用 

分 类 号：R965[医药卫生—药理学]