不同剂量低强度激光血管内照射对实验性糖尿病兔红细胞变形能力的影响及其时间效应  

THE DOSAGE AND TIME EFFECTS OF INTRAVASCULAR LOW LEVEL LASER IRRADIATION ON RED CELL DEFORMABILITY

作　　者：王怡振[1] 史宏敏[1] 于雷[1] 王之光[1] 刘希凡[1] 林南妮[1] 

机构地区：[1]中山医科大学物理教研室,中山医科大学激光医学研究室

出　　处：《中国医学物理学杂志》1996年第4期217-219,共3页Chinese Journal of Medical Physics

摘　　要：本研究首次采用了较大的功率和剂量（５ｍＷ、１０ｍＷ、１８ｍＷ和２５ｍＷ×６０ｍｉｎ）的Ｈｅ－Ｎｅ激光对实验性糖尿病新西兰兔进行了血管内照射，观察了其红细胞变形能力（ＲＣＤ）随剂量和时间的变化。结果发现：①在未实验所选用的功率和剂量范围内，大剂量的照射对ＲＣＤ的影响能较早地表现出来，且更持久。②在改善ＲＣＤ的程度上，剂量（功率）越大，则越表现出优越性，特别是在照射后第１天和第３天，剂量越大的组其平均ＩＦ指数越小。③而照射１２天以后各组无显著性差异，则说明一次照射不可能使ＲＣＤ彻底恢复正常，所以在临床应用时，应进行多次照射。④从照后各天结果的相互比较可以看出，第三天的效果最好，这一结果可为疗程设计提供参考。未次实验过程中未发现溶血现象。Greeater power and dosage (5mW,10mW,18mW and 25mW×6Omin)He-Ne laser was used forthe first time to provide intravascular irradiation to New Zealand ribbits with Alloxan-diabetes.The variations oftheir red cell deformability(RCD)with dosage and time were observed.The results arre:①The group of higherdose influence RCD earlier and longer,and improve RCD more;②On the 12th and 16th day after irradiation,there were no remarkable difference between each test group and control group.It suggests that once irradiationcan not make RCD return to normal completely.Hence more times of irradiation should be given in clinical prac-tice.③Irradiation could have a optimum effect on RCD on the third day after radiation.In addition,no hemolyseswere found in this research.

关 键 词：激光 照射剂量 红细胞变形性 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]