氟化钠对大鼠肝、肾无机元素影响的动态观察  

THE KINETIC OBSERVATION OF THE EFFECT OF SODIUM FLUORIDE ON THE INORGANIC ELEMENTS IN THE LIVER AND KIDNEY OF RATS.

作　　者：马丽英[1] 刘开泰[1] 肖碧玉[1] 王国荃[1] 

机构地区：[1]新疆医学院

出　　处：《现代预防医学》1996年第4期208-209,共2页Modern Preventive Medicine

摘　　要：作者采用动物实验方法对染毒氟化钠后，不同时间大鼠氟中毒症状及肝肾组织中Ｃｕ、Ｚｎ、Ｆｅ、Ｃａ、Ｍｇ、Ｍｎ及Ｐｂ等七种无机元素含量进行了动态观察。结果表明：①受试大鼠于染毒３０天开始出现氟斑牙和骨质疏松，随着染毒时间的延长，骨牙损伤明显加重。②染毒３０天肝组织Ｚｎ含量明显降低，提示：早期氟对肝脏的影响可能与Ｚｎ含量降低有关，染毒９０天和１８０天肝脏中Ｃａ、Ｍｇ明显降低，染毒１８０天肾脏中Ｃａ、Ｍｇ含量也明显降低，说明氟中毒时，肝、肾组织中Ｃａ、Ｍｇ含量的减少可能是肝肾损伤的一个重要原因。本实验为氟中毒病人饮食中，增加Ｚｎ、Ｃａ。he effects of Sodium Fluoride on inorganic elements in the liver and kidney of rats were kinetically observed.Results showed:First,there were both mottled enamel and skeletal fluorosis,after treating fluoride for 30 days and they are more severe more lasting;Secondly,the Zn contents in the liver decreased markedly at 30 days,which suggested that the decrease of Zn contents was related to the effect of fluoride on the liver.At 90 days and 180 days,both Ca and Mg in the liver decreased,but it was only after 180 days of the experiment that both Ca and Mg in the kidney decreased.Therefore,the decline of both Ca and Mg in the liver and kidney might be one of the main causes of liver and kidney injury during the fluorosis.This experiment showed that the patients had to be provided with scientific complement of Zn,Ca and Mg of the diet.

关 键 词：氟化钠 氟中毒 无机元素 肝 肾 

分 类 号：R992[医药卫生—毒理学]