头孢他美酯的合成实验研究  

An Experimental Study on Synthesis of Cefetamet Pivoxil

作　　者：罗喜荣[1] 蒋翠兰[2] 罗小美 

机构地区：[1]贵阳医学院有机化学教研室,贵州贵阳550004 [2]河北化工医药职业技术学院,河北石家庄050031 [3]铜仁地区第二人民医院,贵州铜仁554300

出　　处：《贵阳医学院学报》2006年第5期403-405,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯路线的可行性,研究原料配比、催化剂、反应温度、反应时间等因素对实验结果的影响。方法:在极性非质子性溶剂N,N-二甲基甲酰胺溶液中,在一定反应温度和反应时间下,用碱作催化剂,以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯,并优化反应条件。结果:在极性非质子性溶剂N,N-二甲基甲酰胺溶液中,在三乙胺催化下,反应温度20～23℃,以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯的路线是最佳合成路线,收率可达84%。结论:原料配比、碱、反应温度、反应时间等因素对产品质量、色泽、收率有很大影响。Objective： To investigate the synthesis route of cefetamet pivoxil from iodomethyl pivalate and cefetamet and affecting factors. Methods： Cefetamet pivoxil was synthesized from iodomethyl pivalate and cefetamet in the N, N-dimethylformamide solution, with the presence of base and at 0 -40 ℃. Results： Optimum conditions for cefetamet pivoxil synthesis was summarized that the ratio of iodomethyl pivalate to cefetamet was 0.5：1 in the N ,N-dimethylformamide solution, with the presence of Et3N, and the reaction temperature was 20 -23 ℃. The objective compound was obtained by 84% of the total yield. Conclusion： Quality, color and yield of cefetamet pivoxil are affected by material ratio, catalyst, temperature and reaction time.

关 键 词：抗生素类 温度 时间 碱类 特戊酸碘甲酯 头孢他美酯 

分 类 号：R978.11[医药卫生—药品]