实验性大鼠恶性胸膜间皮瘤的CT表现  

CT Manifestations of Malignant Pleural Mesothelioma in Experimental Rats

作　　者：韩丹[1] 巫北海[2] 何波[1] 

机构地区：[1]昆明医学院第一附属医院影像中心,云南昆明650032 [2]第三军医大学西南医院放射科

出　　处：《实用放射学杂志》2006年第10期1161-1165,共5页Journal of Practical Radiology

基　　金：云南省自然科学基金资助项目(2002C0083M);云南省教育厅科学资助项目(028ZY152)

摘　　要：目的探讨大鼠恶性胸膜间皮瘤(MPM)特征性CT征象。方法W istar大鼠100只,右侧胸膜腔闭式染尘法注入石棉纤维混悬液,每月1次,每次20 mg/m l,连续2月,石棉总剂量为40 mg,对照组用同样方法注入灭菌生理盐水,大鼠垂死时或死亡后立即CT扫描及尸解病理检查。整个动物实验历时2年。结果得到实验组MPM 66例,胸膜增生14例,阴性12例。对照组4只胸膜增生,10只阴性,无胸膜间皮瘤。根据病理改变分为MPM组66例,非MPM组26例,对照组非MPM组14例。胸膜增厚的形态、厚度在实验组MPM组与实验非MPM组及对照组均有差异,结节状胸膜增厚只出现在MPM组,其它组无,特异性为100%。胸膜的平均CT值MPM组其它两组无差异。MPM组胸腔肿块发生率达94.5%,可为肿瘤、脓肿或包裹性积液,其中肿瘤性肿块62.5%。MPM的纵隔改变包括纵隔增宽,纵隔胸膜增厚、不规则及纵隔的移位,以纵隔不规则增宽、纵隔胸膜的改变与非MPM组比较差异有显著性。胸水与临床及尸解相比少见。未见胸内淋巴结肿大。结论大鼠MPM具有一些较特征性的CT征象。Objective To study CT manifestations of the malignant pleural mesothelioma （MPM） in rat. Methods 100 Wistar rats in the test group were injected with asbestos fibrous mixed fluid into closed right chest cavity 20 mg/ml one per month, the overall volume of asbestos was 40 mg, 19 rats in the control group were injected with sterilized saline water of 1 ml per time, totally 2 ml as the same way. Dying or died rats were undergone CT scanning and pathologic examination, the experiment lasted for 2 years. Results In experimental group,there were 66 rats of MPM, 14 cases of pleural hyperplasia and 12 cases without pleural change. There were 4 eases of pleural hyperplasia, 10 cases without pleural change and no one of MPM in the control group. According to pathologic changes, they were divide into 66 eases of MPM, 26 eases of non - MPM in the experimental rats and 14 cases of non - MPM in the control group. The occurrence rate, morphology and thickness of pleural thickening were significant among MPM group, non - MPM group and the control group. The specificity of nodular pleural thickening was 100% . The mean CT number of pleural thickening had no significance. The occurrence rate of masses of MPM in the chest cavity was 94.5%. The masses included tumors, abcesses or encapsulated effusion, the masses of MPM accounted for 62.5%. The mediastinal changes included irregular widening mediastinum, mediastinal pleural changes and masses and so on. But irregular widening mediastinum and adjacent invasion were more common and specified signs. Enlarge lymph nodes were not seen. Conclusion There were some specific CT signs in induced MPM.

关 键 词：大鼠 恶性胸膜间皮瘤 实验 体层摄影术 X线计算机 

分 类 号：R332[医药卫生—人体生理学] R734.3[医药卫生—基础医学]