骨髓基质细胞生物学特性及其在脊髓损伤修复中的应用  

Biological features of bone marrow stromal cells and their application in the recovery of spinal cord injury

作　　者：石永江[1] 刘宏亮[1] 姚忠祥[2] 

机构地区：[1]解放军第三军医大学西南医院康复科 [2]解放军第三军医大学基础部组织胚胎学教研室,重庆市400038

出　　处：《中国临床康复》2006年第41期105-107,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学基金资助(30371630)~~

摘　　要：目的:近来发现骨髓基质细胞具有强大的增殖能力和多向分化潜能,在特定诱导条件下可分化为神经细胞,提示骨髓基质细胞移植为修复脊髓损伤带来了希望。为此就骨髓基质细胞生物学特性及其在脊髓损伤修复中的应用予以综述。资料来源:应用计算机检索PUBMED2000-01/2004-12期间的相关文章,检索词为“MSCs,SCI”,并限定文章语言种类为English。同时计算机检索万方数据库2000-01/2004-12期间的相关文章,检索词为“骨髓基质细胞,脊髓损伤”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应涉及骨髓基质细胞的生物学特征、定向分化、鉴定以及骨髓基质细胞治疗脊髓损伤的研究现状或作用机制等内容。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到38篇相关文献,26篇文献符合纳入标准,排除的12篇文献为内容陈旧或重复。符合纳入标准的26篇文献中,13篇涉及骨髓基质细胞的生物学特征,3篇涉及骨髓基质细胞定向分化为神经细胞的诱导,1篇涉及骨髓基质细胞的鉴定,3篇涉及骨髓基质细胞移植治疗脊髓损伤的研究现状,6篇涉及骨髓基质细胞移植修复脊髓损伤的作用机制。资料综合:骨髓基质细胞具有强大的增殖能力和多向分化潜能,用于细胞移植和基因治疗有许多优势,被视为多种组织细胞移植的替代来源和基因治疗的有效运载工具。骨髓基质细胞在特定的诱导条件下,可以分化为神经细胞。研究提示,取材方便、易于扩增、易于诱导分化的骨髓基质细胞可作为脊髓损伤细胞治疗的一个备选来源,为修复脊髓损伤带来了希望。结论:具有自我更新能力及多向分化潜能的骨髓基质细胞,随着转基因治疗和联合细胞移植的深入研究,将为脊髓损伤的修复带来更加广阔的前景。OBJECTIVE： Recently, it is found that bone marrow stromal cells （MSCs） have great proliferation capability and multi-directional differentiation potential, especially MSCs can differentiate into nerve cells at specific induction, which indicates that MSCs transplantation is a hopeful way for the recovery of spinal cord injury （SCI）. This paper aims to review the biological features of MSCs and their application in the recovery of SCI. DATA SOURCES： An online search at PUBMED between January 2000 and December 2004 was undertaken to identify the related articles with the key words of ＂MSCs, SCI＂, and the language was limited to English. Meanwhile, the Chinese articles were retrieved in Wanfang database during the same period by imputing the key words.of ＂bone marrow stromal ceils, spinal cord injury＂. STUDY SELECTION：After the primary check, the quotation of each literature was looked over. Inclusive criteria： the biological features, orientated differentiation and evaluation of MSCs, together with the current research or mechanism about the treatment of SCI by MSCs. Exclusive criteria： repetitive study or Meta analysis. DATA EXTRACTION： Totally 38 related articles were collected, and 12 of them were excluded due to the dated or repetitive contents. Among 26 articles met the inclusive criteria, 13 ones were about the biological features of MSCs, 3 ones were about the orientated differentiation of MSCs into nerve cells, 1 was about the evaluation of MSCs; 3 ones were about the current researches of the treatment of SCI by MSCs, and 6 ones were about the mechanism of MSCs transplantation in the recovery of SCI. DATA SYNTHESIS：With great proliferation capability and multi- directional differentiation potential, MSCs are dominant in the cell transplantation and gene treatment, thus MSCs are considered as the replacement sources of various tissue cell transplantations and the effective vehicles of gene treatment. Under the specific induction, MSCs may differentiate into nerve cells.

关 键 词：骨髓细胞 脊髓损伤 综述文献 骨髓基质细胞移植 

分 类 号：R651.2[医药卫生—外科学]