Arterial baroreflex function does not influence telomere length in kidney of rats  

作　　者：Xiao-fei ZHANG Rui-fang YANG Jin WANG Lei ZHAO Ling LI Fu-ming SHEN Ding-feng SU 

机构地区：[1]Department of Pharmacology, Second Military Medical University, Shanghai 200433, China

出　　处：《Acta Pharmacologica Sinica》2006年第11期1409-1416,共8页中国药理学报（英文版）

基　　金：Project supported by the grants(№30330650,30472023)from the National Natural Science Foundation of China.

摘　　要：Aim： To investigate the relationship between arterial baroreflex （ABR） function and telomere length in kidney of rats. Methods： Stroke-prone spontaneously hypertensive rats （SHR-SP） and sinoaortic denervated rats （SAD） were used as models with depressed arterial baroreflex. In the first experiments, SHR-SP rats were examined at the age of 24 weeks for both sexes and 40 weeks for female rats. In the second experiments, SAD rats were studied 4 and 35 weeks after SAD operation. Blood pressure was continuously recorded for 4 h in a conscious state. After the determination of baroreflex sensitivity （BRS）, the terminal restriction fragment （TRF） of rat kidney was analyzed using Southern blot. Results： The TRF length was found shorter in： a） male SHR-SP compared with age-matched female SHR-SP; b） female SHR-SP 40 weeks of age compared with 24 weeks of age; c） in rats 35 weeks after operation compared with rats 4 weeks post operation in both sham-operated and SAD rats. Conclusion： In SHR-SP, the TRF length did not correlate with BRS. In addition, SAD did not affect TRF length at either 4 or 35 weeks post-surgery. It may be concluded that baroreflex function does not influence the terminal restriction fragment （TRF） length in rats.Aim： To investigate the relationship between arterial baroreflex （ABR） function and telomere length in kidney of rats. Methods： Stroke-prone spontaneously hypertensive rats （SHR-SP） and sinoaortic denervated rats （SAD） were used as models with depressed arterial baroreflex. In the first experiments, SHR-SP rats were examined at the age of 24 weeks for both sexes and 40 weeks for female rats. In the second experiments, SAD rats were studied 4 and 35 weeks after SAD operation. Blood pressure was continuously recorded for 4 h in a conscious state. After the determination of baroreflex sensitivity （BRS）, the terminal restriction fragment （TRF） of rat kidney was analyzed using Southern blot. Results： The TRF length was found shorter in： a） male SHR-SP compared with age-matched female SHR-SP; b） female SHR-SP 40 weeks of age compared with 24 weeks of age; c） in rats 35 weeks after operation compared with rats 4 weeks post operation in both sham-operated and SAD rats. Conclusion： In SHR-SP, the TRF length did not correlate with BRS. In addition, SAD did not affect TRF length at either 4 or 35 weeks post-surgery. It may be concluded that baroreflex function does not influence the terminal restriction fragment （TRF） length in rats.

关 键 词：age baroreflex sensitivity HYPERTENSION SHR-SP telomere length 

分 类 号：R692[医药卫生—泌尿科学]