急性心肌梗死介入治疗患者血浆晚期氧化蛋白产物水平的变化  

Level of Advanced Oxidation Protein Products in patients with acute myocardial infarction who underwent PCI

作　　者：邓新桃 何倩 赵建祥 马根山[2] 冯毅[2] 王积慧[2] 胡善友 

机构地区：[1]兴化市人民医院心内科,江苏兴化225700 [2]东南大学附属中大医院心内科,江苏南京210009

出　　处：《江苏大学学报（医学版）》2006年第5期423-426,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的：通过检测急性心肌梗死（AMI）介入治疗患者体内晚期蛋白氧化产物（AOPP）的水平，观察氧化应激在体内的变化过程。方法：入选74例AMI[28例急诊经皮冠状动脉介入治疗（PCI）和46例择期经皮冠状动脉介入治疗]及21例非冠心病（均经造影证实）患者，分别采集外周静脉血标本人院即刻、24h和48h 3个时间点，在紫外荧光340nm及酸性条件下测定血清标本的光密度。结果：AOPP浓度AMI择期PCI组（236．42±30．41）μmol／L与AMI急诊PCI组（97．58±23．41）μmol／L（P〈0．01）及非冠心病组（57．41±13．60）μmol／L（P〈0．05）均有显著性差异（P〈0．01），AMI择期PCI组明显升高，而AMI急诊PCI组（97．58±23．41）μmol／L，与非冠心病组无显著差异。结论：氧化应激是AMI发生发展过程中的重要环节，AMI择期PCI患者血清AOPP浓度显著升高，AMI发病早期（3-12h）内的积极干预（介入及药物治疗）可抑制AOPP大量生成。Objective： To examine the advanced oxidation protein products （AOPP） in patients with acute myocardial infarction （AMI） who underwent PCI and discuss the development of AOPP in AMI patients. Methods： AOPP were determined by measurements of optical density （OD） at 340 nm under acidic conditions in the plasma of 74 AMI patients （include 28 patients underwent emergency PCI ,46 patients underwent selective PCI）and 21 non-coronary artery disease （non-CAD） patients. Plasma collected immediately ,post-24 h and post-48 h after patients were recruited. Results： Compared with patients with AMI who underwent emergency PCI（97.58 ± 23.41 ） μmol/L, significantly higher serum AOPP were detected in patients with AMI who underwent selective PCI（ 236.42 ± 30.41 ） μmoL/L（ P 〈 0.01 ） ;AOPP levels have significant difference between patients with AMI who underwent selective PCI and patients without CAD （57. 41 ± 13.60） μmoL/L（ P 〈0.01 ）,no difference between patients with AMI who underwent emergency PCI and patients without CAD （P 〉 0.05 ）. Conclusion： Oxidative stress was an important step in development of AMI, Advanced Oxidation Protein Products（AOPP） in serum of AMI underwent selective PCI patients increased significantly, active intervention（PCI＆drugs） will significantly suppress AOPP at the beginning of AMI（3 -12 h）.

关 键 词：急性心肌梗死 氧化产物 经皮冠状动脉介入术 

分 类 号：R542.22[医药卫生—心血管疾病]