当归和黄芪的比例变化对当归补血汤活性成分含量的影响  

Affect of Ratio Changes of Radix Angelicae Sinensis to Radix Astragali in Danggui Buxue Tang( DBT) on the Contents of Effective Constituents

作　　者：赵奎君[1] 钟萌[1] 杨恩来[1] 董婷霞[2] 詹华强[2] 

机构地区：[1]首都医科大学附属北京友谊医院,北京100050 [2]香港科技大学生物系

出　　处：《中国药师》2006年第11期1032-1034,共3页China Pharmacist

摘　　要：目的:通过研究当归、黄芪的比例变化对当归补血汤活性成分含量的影响探讨当归补血汤中当归、黄芪配伍比例的合理性。方法:利用高效液相色谱法和比色法,测定了当归和黄芪配伍比例分别为:1:1,1:3,1:5,1:7,1:10的当归补血汤中阿魏酸、藁本内酯、黄芪甲苷、芒柄花素、毛蕊异黄酮及总多糖的含量。结果:在5个比例的当归补血汤中,李东垣的经其方当归、黄芪(1:5)中阿魏酸、黄芪甲苷、芒柄花素、毛蕊异黄酮及总多糖的含量最高。结论:当归补血汤中当归和黄芪1:5的配伍是合理的,应该遵循古人的用药经验。Objective： To study the rationality of weight ratio of Radix Angelicae Sinensis to Radix Astragali in DBT by determined the contents of effective constituents in the different ratio of DBT. Method： The contents of astragaloside IV, calycosin, formononetin, ferulic acid, ligustilide and total polysaccharide in 5 ratios of DBT（ Radix Angelicae Sinensis to Radix Astragali： 1 ： 1, 1 ： 3, 1 ： 5,1 ： 7, 1：10） were determined by HPLC and UV spectrophotometry. Result： Significantly, higher contents of astragaloside IV, calycosin, formononetin, ferulic acid and total polysaccharide were found in DBT with Radix Angelicae Sinensis and Radix Astragali in a 1 ： 5 ratio. Conclusion ： The 1 ： 5 ratio of Radix Angelicae Sinensis and Radix Astragali in DBT described in 1247 A.D. by Li Dongyuan is reasonable and we should not change the formulation of DBT easily.

关 键 词：当妇补血汤 配伍比例 活性成分含量 

分 类 号：R289.5[医药卫生—方剂学]