邻卤苯乙酸的合成  

Synthesis of o-halophenylacetic acid

作　　者：蔡可迎[1] 王桃霞[1] 高媛[1] 李雪力[1] 宗志敏[1] 魏贤勇[1] 

机构地区：[1]中国矿业大学化工学院,江苏徐州221008

出　　处：《化工进展》2006年第10期1214-1216,共3页Chemical Industry and Engineering Progress

基　　金：中国矿业大学碳资源高效利用优秀创新团队建设项目(2004ZCX007)

摘　　要：在乙醇钠催化下使邻硝基甲苯与草酸二乙酯缩合,然后经水解、双氧水氧化和盐酸酸化得到邻硝基苯乙酸,收率62%。在20%NaOH水溶液中,FeO(OH)催化水合肼还原邻硝基苯乙酸得到邻氨基苯乙酸,经重氮化和卤置换反应得到邻卤苯乙酸,收率65%～73%。总收率为40%～45%。o-nitrophenylacetic acid was synthesized by C2H5ONa-catalyzed condensation of o-nitrotoluene with diethyl oxalate and subsequently by hydrolysis, oxidation with H2O2 and acidation with HCl. The yield was about 62 %. It was further converted to o-halophenylacetic acid by FeO（OH）-catalyzed reduction with hydrazine hydrate in 20% NaOH aqueous solution, diazonation and substitution with haloatoms. The yield was 65 % -73 %. The overall yield was about 40% -45 %.

关 键 词：邻卤苯乙酸 邻硝基苯乙酸 邻硝基甲苯 合成 

分 类 号：TQ245.3[化学工程—有机化工]