新生儿脑~18F-FDG PET显像初步研究  

Preliminary investigation of brain ~18F-FDG PET imaging in neonate

作　　者：金榕兵[1] 张荷[1] 李奇明[1] 范西江[1] 唐维佳[1] 李华强[2] 史源[2] 赵景宁 唐仕芳[2] 

机构地区：[1]第三军医大学第三附属医院野战外科研究所核医学科,重庆400042 [2]第三军医大学第三附属医院野战外科研究所儿科,重庆400042

出　　处：《中华核医学杂志》2006年第5期292-294,共3页Chinese Journal of Nuclear Medicine

基　　金：重庆市科委科研基金(2004BB5249)

摘　　要：目的观察部分新生儿肺炎患儿和早产儿的脑^(18)F-脱氧葡萄糖(FDG)PET 显像图,从代谢角度分析其脑功能。方法对9例新生儿肺炎患儿及7例早产儿行脑^(18)F-FDG PET 检查。结果新牛儿正常腑^(18)F-FDG PET 影像与成人及儿童明显不同,整个脑的结构不清晰,其葡萄糖代谢活性区主要集中在丘脑、小脑、感觉运动皮质、基底节等脑组织,其中丘脑摄取^(18)F-FDG 最多,大脑皮质摄取^(18)F-FDG 的量较低。分别用1、2、3 min 的透射采集作衰减校正,所得图像质量无明显差异。结论脑^(18)F-FDG PET 显像可作为研究新生儿脑功能代谢行之有效的方法之一。对新牛儿行脑^(18)F-FDGPET 显像应尽量减少透射采集时间。Objective To study brain ^18F-fluorodeoxyglucose （FDG） PET imaging and to understand its metabolic function in neonate with pneumonia and premature infants. Methods Nine neonate with pneumonia and seven premature infants were examined with routine ISF-FDG PET brain scan. Results The brain ^18F-FDG PET image of neonate was significantly different from that of adult and child. The structure of whole brain was not clearly demarcated. The active glucose metabolic areas were in thalamus, cerebellum, sensorimotor cortex and basal ganglia. The ^18F-FDG uptake was most in thalamus, while least in cerebral cortex. The image quality showed no significant difference among 1, 2 and 3 min transmission scan for attenuation correction. Conclusions ~s F-FDG PET brain imaging may be one of effective methods to study cerebral function and metabolism in neonate. But the CT transmission time should reduce to be the shortest.

关 键 词：婴儿 新生 脑 体层摄影术 发射型计算机 脱氧葡萄糖 

分 类 号：R722.1[医药卫生—儿科]