乙酰柠檬酸三丁酯的生产和应用  

Development of the Production and Application of Non-toxic Acetyltributyl Citrate

作　　者：梅允福[1] 季刚 班丽娜[3] 

机构地区：[1]无锡石油化工总厂,江苏无锡214016 [2]蓝星总公司,北京100000 [3]广西大学化工系,530004

出　　处：《广州化工》2006年第5期17-18,共2页GuangZhou Chemical Industry

摘　　要：由柠檬酸和正丁醇在复合催化剂存在下合成柠檬酸三丁酯。它再与醋酐于复合催化剂下合成乙酰柠檬酸三丁酯。酯化反应的最佳条件为:柠檬酸与正丁醇的物质量之比为1:3．5,于100℃～130℃反应,催化剂质量为柠檬酸的0．8％,反应时间2．8 h,酯化率>99．4％,纯度>99．5％;乙酰化最佳反应条件为:柠檬酸三丁酯与醋酐物质的量之比为1:1．4,于60℃～85℃反应时间为1．4 h,催化剂用量为柠檬酸三丁酯的0．01％(质量),乙酰化转化率>99．5％,纯度为99.5％。Non - toxic tributyl citrate was synthesized by citric acid and n - butanol. The non - toxic acetyl tributyy citrate was synthsized by tributyl citrate and acetyloxide in the presence of compounded catalyst. The optinum esterification conditions were determined as follows： molar ratio of citric acid to n - butanol was 1 ： 3.5, reaction temperature 100℃- 130℃, quantity of catalyst accounted for 0.8 % of citric acid and reaction time was 2.8 hs. The final corversion of more than 99.4 % with a purity of more than 99.5 %. The optinun acetyla- tion conditions were determined as follows： molor ratio of tributyl citrate to acetyloxide was 1 ： 1.4, reaction temperature 80℃ - 85℃, reaction time 1.4 hs, quanitiy of catalyst accounted for 1% of tributyl citrate. Resulted in final conversion of more than 99.5 %. The optinun acetylation conditions were determined as follows：molor ratio of tributyl citrate to acetyloxide was 1 ： 1.4, reaction temperature 80℃ -85℃, reaction time 1.4 hs, quantity of catalyst accounted for 1% of tributyl citrate. Resulted in final conversion of more than 99.5 % with a purity of more than 99.5 %.

关 键 词：乙酰柠檬酸三丁酯 柠檬酸三丁酯 醋酐 复合催化剂 生产 应用 

分 类 号：TQ414.99[化学工程]