^(131)I-MIBG心肌显像临床应用的探讨  

The clinical utility of ^(131)I-MIBG myocardial imaging

作　　者：川玲[1] 朱家瑞[1] 赵文锐[1] 高淑芬[1] 许根祥[1] 王新强[1] 田嘉禾[2] 张景明[2] 

机构地区：[1]海军总医院核医学科 [2]解放军总医院核医学科

出　　处：《海军总医院学报》1996年第4期211-214,共4页Journal of Naval General Hospital of PLA

摘　　要：本研究对正常对照组(NC)、原发性高血压病组(EH)、陈旧性心肌梗塞组(OMI)和扩张性心肌病组(DCM)共60例患者行早期(10Min)及延迟(4h)^(131)I间位碘代苄胍(MIBG)平面心肌显像,采用心/纵隔(H/M)作相对半定量计数分析.结果提示NC组早期H/M均低于延迟;早期与延迟H/M呈正相关;各疾病组早期及延迟H/M多低于NC组;三个疾病组MIBG的洗脱率(WR)均高于NC组.各疾病组心肌的这种低摄取和高清除反映了心肌肾上腺素能神经功能不同程度的受损.Purpost: This study was to investigate the clinical application value of 131I-MIBGmyocardial imaging. Methods: 13lI-MIBG myocardial imaging was applied to 60 cases with varioustypes of cardiac diseases,such as old myocardial infarction,hypertension,dilate cardiomyopathy andvolunteers compared with B ultrasound. Results: The Heart/mediatinum uptake ratio (H/M) ofMIBG were decreased in early and delay images in disease groups respectively. High washout(WR) also were seen in various cardiac disease Conclusions: The lower H/M uptake ratio andhigh washout ratio in 131I-MIBG myocardial imaging in diseases groups seems to be nonspeciticityto disease type,but is a common feature of damaged or failing myocardium. It may reflect the dis-function of myocardial adrenergic nerves and have value in diagnosis,analysis condition of diseaesas well the evaluation of treatment effects.

关 键 词：心肌显像 心肌梗塞 扩张性心肌病 

分 类 号：R542.22[医药卫生—心血管疾病]