高胆固醇饲料诱导兔红细胞膜脂蛋白、脂质过氧化和膜流动性的改变  

Experimental Observation on Changes of Lipoproteins, Lipidperoxidates and Fluidity on Rabbits Erythrocyte Membranes with Hypercholesterol Food Induces/

作　　者：周本财 马建林 田元 郭和平 李明慧 

出　　处：《微循环学杂志》1996年第3期41-42,共2页Chinese Journal of Microcirculation

摘　　要：观察１４只雄性家兔在高胆固醇饲料的喂养下可能诱发的红细胞膜脂蛋白、脂质过氧化和膜流动性的改变。在喂养二个月前后的对比观察中，发现血浆总胆固醇和低密度脂蛋白胆固醇显著升高（Ｐ＜０．００１），红细胞膜低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、膜共轭双烯和膜流动性均显示明显差异（Ｐ＜０．０１～０．００１）。结果提示，高胆固醇饲料不仅可以引起高脂血症，而且可以诱导红细胞膜脂蛋白成分、脂质过氧化和膜流动性的改变。红细胞膜的这些物理和化学性质的改变。The changes of lipoproteins, lipidperoxidated and fluidity on 14 rabbits erythrocyte membranes with hypercholesterol food induces after persistin for 2 months were observed. In comparison before and after feed, the results showed that the plasma TC and LDL C was significantly increased, erythrocyte membranes LDL C, HDL C, CD and LFU was significantly difference. The results suggest: hypercholesterol food not only induce hyperlipemia, besides, it could induce changes of lipoproteins composition, lipidperoxidates and fluidity of erythrocyte membrane. Changed of physics and chemistry property of them could relative to rheological property of microvascular.

关 键 词：微循环疾病 红细胞膜 脂蛋白 过氧化脂质 

分 类 号：R543[医药卫生—心血管疾病]