正常人听觉诱发电位P50的特征  

Characteristics of Auditory Evoked Potential P50 in Normal Controls

作　　者：陈兴时[1] 张明岛[1] 王红星[1] 楼翡璎[1] 梁建华[1] 陈冲[1] 陈欣伟[1] 

机构地区：[1]上海市精神卫生研究所神经生理室,上海200030

出　　处：《上海交通大学学报（医学版）》2006年第10期1165-1167,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(30470626);上海市科委基金(054119534)资助项目

摘　　要：目的研究正常人听觉诱发电位P50的特征。方法应用美国Nicolet Bravo脑电生理仪，采用条件刺激（S1）-测试刺激（S2）模式对92名健康受试者进行听觉诱发电位P50检测。结果正常人S1-PS0潜伏期（60．9±12．7）ms，波幅（5．4±3．4）μV；S2-P50潜伏期（66．1±12．5）ms，波幅（2．0±1．4）μV；S2-P50波幅显著低于S1-P50波幅（P〈0．01）。S2／S1波幅比值（45．4±24．6）％，其95％可信区间42．7％～48．1％；波幅S1-S2和100（1-S2／S1）分别为（3．2±2．9）μV和（54．3±24．6）％，95％可信区间分别为2．8～3.5μV和51．6％～57．0％。男女间S1-P50与S2-P50的潜伏期和波幅无显著差异（P〉0．05）。结论听觉诱发电位P50是反映大脑感觉门功能状态指标，其较佳表达式是波幅S1-S2和100（1-S2／S1）两种结合。Objective To observe the characteristics of auditory evoked potential P50 in normal controls. Methods Auditory evoked potentials P50 were recorded in 92 normal controls by the conditioning（ S1 ）/testing（ S2 ） paradigm presented with auditory double clicks stimuli, using American Nicolet Bravo instrument. Results The peak latency and amplitude of S1-P50 from Cz site were （60.9 ± 12.7 ） ms and （5.4 ± 3.4）μV, and the peak latency and amplitude of S2-P50 from Cz site were （66.1 ±12.5） ms and （2.0 ±1.4）μV. The amplitude of S2-P50 reduced significantly as compared with that of S1-P50 （P 〈0.01 ）. The S2/S1 ratio and its 95% confidence interval were （45.4 ± 24.6）% and 42.7%-48.1%. The normal ranges of S1-S2 and 100（1-S2/S1） were （3.2±2.9）μV and （54.3 ± 24.6） % , and their 95% confidence intervals were 2.8 - 3.5 μV and 51.6%- 57.0%. There were no significant differences between male and female groups in the P50 amplitude and latency. Conclusion Auditory evoked potential P50 might be a new index of brain sensory gating, and S1 -S2 and 100（ 1 -S2/S1 ） are the optimal formula of P50.

关 键 词：正常人 听觉诱发电位 P50 感觉门 条件-测试刺激模式 

分 类 号：R33[医药卫生—人体生理学]