吡格列酮和肿瘤坏死因子α对3T3-L1脂肪细胞脂联素受体mRNA表达的影响  

Effects of pioglitazone and tumor necrosis factor-α on adiponectin receptor mRNA expression in 3T3-L1 adipocytes

作　　者：刘玲[1] 胡国平[1] 王佑民[1] 杨明功[1] 

机构地区：[1]安徽医科大学第一附属医院内分泌科,合肥230022

出　　处：《中华内分泌代谢杂志》2006年第5期484-486,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：安徽省自然科学基金(03043719)

摘　　要：观察吡格列酮(PIO)和TNF-α对313-L1脂肪细胞中两种脂联素受体(AdipoR)mRNA表达的影响,发现AdipoR mRNA在313-L1细胞分化过程中的表达呈逐渐上调趋势；PIO能增加未分化和已分化313-L1细胞的AdipoR mRNA表达,且其促进效应与时间、剂量呈依赖关系；TNF-α对AdipoR mRNA的表达无影响。The effeets of pioglitazone （PIO） and tumor necrosis faetor-α（TNF-α） on two kinds of adiponectin receptor （AdipoR） mRNA expression were observed in 3T3-L1 adipoeytes by RT-PCR. AdipoR mRNA expression was up-regulated during 3T3-L1 preadipoeyte differentiation： PIO could increase the AdipoR mRNA level expressed in undifferentiated and diffderentiated 3T3-L1 adipoeytes in a time- and dose-dependent manner, and TNF-α had no influence on the expression of AdipoR mRNA.

关 键 词：受体 脂联素 3T3-L1细胞 细胞分化 吡格列酮 肿瘤坏死因子Α 

分 类 号：R587.1[医药卫生—内分泌] R543.5[医药卫生—内科学]