KRAB型锌指蛋白(KZNF)的研究进展  

Progress in the Study of KRAB Zinc Finger Protein

作　　者：田春艳[1] 张令强[1] 贺福初[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所系统生物学研究室,北京100850

出　　处：《遗传》2006年第11期1451-1456,共6页Hereditas（Beijing)

基　　金：国家高技术研究发展计划项目(863计划)(编号:2004AA221100;2005AA220060;2002BA71A02-5);国家自然科学基金(编号:30321003;30600310)资助~~

摘　　要：KRAB型锌指蛋白是哺乳动物中最大的转录调控因子家族,它的多数成员在基因组上成簇分布。其结构特征是N端含有KRAB结构域,C端含有多个C2H2型锌指结构。KRAB结构域为一蛋白质-蛋白质相互作用区,可以与多种协同转录抑制因子和转录因子结合,使KRAB型锌指蛋白作为转录因子和／或转录调控因子发挥依赖于DNA结合的转录抑制功能,在胚胎发育、细胞分化、细胞转化及细胞周期的调控中发挥重要功能。The zinc finger proteins containing the Kruppel-associated box domain （KRAB） constitute the largest single family of transcriptional regulators in mammals. Many genes encoding members of this family are arranged in clusters. KRAB-containing proteins are characterized by the presence of 4 and over 30 C2H2 zinc-finger motifs and a KRAB domain near the amino terminus of the protein. KRAB domain behaving as a protein-protein interaction domain could bind to corepressor proteins and/or transcription factors, and that the KRAB-containing proteins could act as a repressor or corepressor and play a key role in transcriptional repression. Members of the family are involved in embryonic development, cell differentiation, cell proliferation, apoptosis, neoplastic transformation and cell cycle regulation.

关 键 词：KRAB KZNF C2H2型锌指 KAP-1 转录抑制 

分 类 号：Q75[生物学—分子生物学]