单纯性肥胖儿童胰岛素抵抗和胰岛β细胞分泌功能变化  

Changes of Insulin Resistance and β-Cell Secrete Function in Children with Simple Obesity

作　　者：许小花[1] 

机构地区：[1]浙江大学医学院附属儿童医院内分泌科

出　　处：《实用儿科临床杂志》2006年第20期1385-1386,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的了解单纯性肥胖儿童胰岛素抵抗及胰岛β细胞功能。方法对单纯性肥胖和正常对照儿童进行口服糖耐量试验(OGTT)和胰岛素释放试验,测定其血糖和胰岛素水平。采用稳态模型评估法(HOMA)计算胰岛素抵抗指数(HOMA-IR),胰岛素敏感指数(HOMA-IAI),胰岛素分泌指数(HOMA-IS),服葡萄糖后30 min胰岛素增值与血糖增值的比值(ΔI30/ΔG30)、胰岛素曲线下面积(INSAUC)。结果HOMA-IR≥2.8者24例(38.7%),为胰岛素抵抗。肥胖组空腹血糖(FPG)、HOMA-IS与对照组比较无统计学差异。两组餐后2 h血糖、空腹胰岛素、餐后2 h胰岛素。HOMA-IR、HOMA-IAI、ΔI30/ΔG30、INSAUC均有统计学差异。结论单纯肥胖儿童不仅有胰岛素抵抗,同时存在餐后胰岛β细胞分泌功能异常。Objective To explore the changes of insulin resistance and β- cell secrete function in children with simple obesity. Methods Levels of glucose and insulin were detected with oral glucose tolerance test（OGTT）. Homeostasis model assessment insulin resistance （ HOMA - IR） = fasting plasma glucose （FPG）×fasting insulin（FINS）/22.5, homeostasis model assessment insulin aeschynomenous index （HOMA-IAI） = 1/（FPG×FINS） ,index of insulin increment to gluncose increment at 30 min（△Ⅰ30/△30） = （Ⅰ30-Ⅰ0）/（G30 - G0） post oral glucose, area under the curve of insulin（INSAUC） - 0.5×FINS ＋ INS30 ＋ INS60 ＋ INS120 ＋ 0.5×INS180 were measured. Results HOMA - IR≥2.8 was observed in 38.7 % cases. PFG, homeostasis model assessment in sulin secrete（ HOMA-IS） showed no difference between obesity and control groups. Two hours PG,FINS,2 h INS,HOMA-IAI,△Ⅰ30/△G30, INSAUC showed significant difference between obesity and control groups. Conclusion There are insulin resistance and changes of β-cell secrete after meals in children with obesity.

关 键 词：肥胖症 胰岛素抗药性 Β细胞分泌功能 儿童 

分 类 号：R725.8[医药卫生—儿科]