伴抗基膜自身抗体的皮肤异色病样淀粉样变病  

Poikiloderma-like cutaneous amyloidosis with deposition of autoantibodies to the basement membrance zone

作　　者：张黎黎[1] 涂平[1] 武玲慎[1] 陈伟[1] 杨勇[1] 

机构地区：[1]北京大学第一医院皮肤性病科,北京100034

出　　处：《临床皮肤科杂志》2006年第11期713-714,共2页Journal of Clinical Dermatology

摘　　要：报告1例伴抗基膜自身抗体的皮肤异色病样淀粉样变病。患者男,37岁。双上肢、上腰腹部及面颈部起丘疹、红斑、张力性水疱,色素沉着和色素减退相间,无自觉症状7年。皮损组织病理学检查示表皮基膜下有红色团块样物质,淋巴细胞呈带状浸润,可见噬黑素细胞,刚果红染色阳性。直接及间接免疫荧光示基膜带有IgG、C3沉积。A case of poikiloderma-like eutaneous amyloidosis with deposition of autoantihodies to the basement membrane zone is reported.A 37-year-old male presented with usymptomatic poikilodermatous skin lesion,lichenoid papules and tense blisters on his upper extremities,waists ,abdomen,face and neck for 7 years.Skin biopsy revealed eosinophilic amorphous globules below the basement membrane zone,with band-like infiltration of lymphocytes and melanophages.It showed posistive staining results with Conga red.The deposition of IgGand C3 along the basement membrane zone was demonstrated by direct and indirect immunoflorescence.

关 键 词：淀粉样变病 皮肤 皮肤异色 水疱 免疫球蛋白 

分 类 号：R597.2[医药卫生—内科学]