小儿骨髓增生异常综合征临床特点  

Clinical Analysis of Myelodysplastic Syndromes in Children

作　　者：杨昆[1] 李强[1] 赵亚宁[1] 

机构地区：[1]四川大学华西第二医院儿科,四川成都610041

出　　处：《华西医学》2006年第4期743-744,共2页West China Medical Journal

摘　　要：目的：探讨小儿骨髓增生异常综合征的临床特点。方法：回顾性分析我院25例MDS的临床资料。结果：25例患儿男性18例，女性7例，发病年龄4月-12岁，中位年龄8岁。最常见的临床表现为面色苍白（92％），发热（72％），皮肤黏膜出血（60％）。所有患儿均有一系或一系以上血细胞减少、骨髓病态造血，分型RA2例，RAS2例，RAEB14例，RAEB-T6例，CMML1例。随访7例，2例转变为急性非淋巴细胞白血病。结论：儿童病情进展快，常规治疗效果差，需早期作出诊断。Objective： To discuss the clinical characteristics of MDS in children. Method： 25 patients with MDS were analyzed by the method of retrospective study. Male 18, female 7. The age of onset in these cases was from 4 months to 12 years and the medium age is 8 years. Results： The common clinic manifestations were pale （92%）, fever （72%）, mucocutaneous hemorrhage （60%）. All of these patients were manifested cytopenia in one or more abnormal hematopoietic systems, dyshemopoesis both in blood and bone marrow examination, including RA in2, RAS in 2, RAEB in 14, RAEB - T in 6 and CMML in 1.2 in 7 patients followed were transformed into acute nonlymphocytic leukemia. Conclusion： Pathogenetic conditions of MDS in children progress fast. The effect of routine methods is poor, early diagnosis is essential.

关 键 词：骨髓增生异常综合征 小儿 

分 类 号：R725.5[医药卫生—儿科]