串珠镰刀菌素对大鼠心肌琥珀酸脱氢酶,细胞色素C氧化酶及H^+-ATP酶活力的影响  

Effect of Moniliformin on the activity of some enzymes in isolated rat heart

作　　者：万洪忠[1] 夏弈明[1] 哈鹏程[1] 许洁[1] 

机构地区：[1]中国预防医学科学院营养与食品卫生研究所,北京100050

出　　处：《卫生研究》1996年第3期148-150,共3页Journal of Hygiene Research

基　　金：国家"八五"攻关项目

摘　　要：以大鼠心肌匀浆作酶源,观察串珠镰刀菌素对琥珀酸脱氢酶、细胞色素 C 氧化酶及H^+-ATP 酶活力的影响。结果表明串珠镰刀菌素对琥珀酸脱氢酶和细胞色素 C 氧化酶呈竞争性抑制作用,对 H^+-ATP 酶呈非竞争性抑制作用,这些是串珠镰刀菌素毒性机理的新发现。The effect of Moniliformin (MF) on the activities of succinic dehydrogenase (SDH),cytochrome C oxi- dase (CCO) and H^+-adenosine triphosphatase (H^+-ATPase) was studied in the homogenate of isolated rat hearts.The results show that there is a eompetitive inhibition of MF with SDH and CCO,but a noncompeti- tive inhibition with H^+-ATPase.These are the toxic mechanism of MF discovered at the first time.

关 键 词：串珠镰刀菌素 琥珀酸脱氢酶 细胞色素 克山病 

分 类 号：R542.3[医药卫生—心血管疾病]