基质金属蛋白酶-2及组织金属蛋白酶抑制物-2在子宫内膜异位症中的表达及其临床意义  

Expression and Clinical Significance of Matrix Metalloproteinase-2 and it Tissue Inhibitors of Metalloproteinase-2 in Endometriosis

作　　者：肖云琴[1] 朱波[1] 付芬[2] 

机构地区：[1]南昌大学第三附属医院妇产科,江西南昌330008 [2]南昌大学第二附属医院妇产科,江西南昌330006

出　　处：《实用临床医学（江西）》2006年第10期116-118,共3页Practical Clinical Medicine

摘　　要：目的观察MMP-2和TIMP-2在子宫内膜异位症中的表达及意义。方法应用免疫组化(S-P)法检测20例正常子宫内膜、20例子宫内膜异位症的在位内膜及45例异位内膜组织中MMP-2和TIMP-2蛋白的表达。结果:MMP-2在内异症在位内膜组织、异位内膜组织阳性表达率分别与正常内膜组织比较均有显著性差异(P<0.01);异位内膜阳性率高于在位内膜,但在统计学上无显著性差异(P>0.05)。TIMP-2在异位内膜组织的阳性表达率与正常内膜组织、EM在位内膜组织相比均有显著性差异(P<0.05);在位内膜组织的阳性表达率低于正常内膜组织,但在统计学上无显著性差异(P>0.05)。结论:在子宫内膜异位症中MMP-2的高表达,TIMP-2蛋白的低表达,在子宫内膜异位症的发生、发展过程中具有重要作用。Objective To study the clinical significance and expression of matrix metalloproteinase-2 （MMP-2） and tissue inhibitor of matrix metalloproteinase-2 （TIMP-2） in endometriosis. Methods：The expressions of MMP-2 and TIMP-2 in 20 normal endometriums as well as in 45 ectopic endometriums and 20 eutopic endometriums in endometriosis are detected by immunohistochemistry. And the results are analyzed with statistical software SPSS12.0. Results：The positive rates Of MMP-2 in ectopic and eutopic endometriotic tissues are significantly higher than those in the normal endometrium（P〈0.01）, however, without significant differences in the statistics（P 〉0.05）. The expression levels of TIMP-2 in ectopic endometriotic tissues was significantly lower than those in the normal endometrium and eutopic endometriotic tissue（P〈0.05）, which they were no significant difference in the statistics （P〉0. 05）. Conclusion： The expression levels of MMP-2 and the expression levels of TIMP-2 in endometriosis tissues was lower than those in the normal endometrium tissue,which plays an important role in the creating and developing of the endometriosis.

关 键 词：基质金属蛋白酶-2 组织金属蛋白酶抑制物-2 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]